Computational Statistics seminars

Remarkable advances in experimental neuroscience now enable us to simultaneously observe the activity of many neurons, thereby providing an opportunity to understand how the moment by moment collective dynamics of the brain instantiates learning and cognition. However, efficiently extracting such a conceptual understanding from large, high dimensional neural datasets requires concomitant advances in theoretically driven experimental design, data analysis, and neural circuit modeling. We will discuss how the modern frameworks of high dimensional statistics and deep learning can aid us in this process. In particular we will discuss: how unsupervised tensor component analysis and time warping can extract unbiased and interpretable descriptions of how rapid single trial circuit dynamics change slowly over many trials to mediate learning; how to tradeoff very different experimental resources, like numbers of recorded neurons and trials to accurately discover the structure of collective dynamics and information in the brain, even without spike sorting; deep learning models that accurately capture the retina’s response to natural scenes as well as its internal structure and function; algorithmic approaches for simplifying deep network models of perception; optimality approaches to explain cell-type diversity in the first steps of vision in the retina.

Locality-sensitive hashing is widely used for high-dimensional nearest-neighbor search. This talk develops another view of hashing as a biased sampling method for density-estimation queries. Given a point set and a query, one may estimate kernel density by summing distance-dependent influence functions, or count points within a chosen radius. A linear scan is costly for large datasets and many queries. The presentation surveys recent methods that preprocess the data and use locality-sensitive hashing to construct unbiased estimators for these problems and their extensions. It covers joint work with Arturs Backurs, Piotr Indyk, Vishnu Natchu, Paris Syminelakis, and Xian (Carrie) Wu.