Bio-Informatics

EMBL-EBI seeks a Bioinformatics Developer for DECIPHER, a platform supporting rare-disease research and clinical interpretation of genetic variation. The developer will evaluate and integrate genomic and phenotype resources, deploy analysis tools, design database structures and interfaces, investigate data problems and work with clinical and research collaborators. The role is based in Hinxton with hybrid working and may be full time or 80% time. The advert gives a closing date of 8 October 2026 at 23:59 CET.

Train in pathogen genomic epidemiology and bioinformatics through a PhD registered at Wits in Johannesburg. NICD mentors lead the work, with US co-mentors at Pittsburgh or CDC and part of the training expected in the United States. Apply by 10 October 2026 using the programme’s email instructions. Submit a CV, motivation, two references, MSc certificate and transcript, and South African identification. Opportunities start as soon as possible.

David Gomez-Varela’s group investigates human skin host–microbiome interactions using metaproteomics, quantitative mass spectrometry, microbiology, robotics and AI-assisted data analysis. The LEO Foundation-supported project studies the health–disease dynamics of the skin metaproteome in human samples, with collaborations spanning basic science, bioinformatics and clinical research. The researcher will lead microbiological projects, plan or perform mass-spectrometry experiments, analyse data with established pipelines, write manuscripts and support funding and collaborative projects. The three-year position runs until November 2029 and pays EUR 5,104.30 gross per month under the university collective agreement. Applications are screened on a rolling basis until 10 October 2026; the official vacancy gives document and email-submission instructions.

EMBL-EBI seeks a scientific developer for the Open Targets Safety 2.0 project. The role builds machine-learning and data-processing pipelines that extract drug side-effect evidence from publications, clinical trials and drug labels, map it to biomedical ontologies, and integrate results with ChEMBL and the Open Targets Platform. The researcher will help curate training data, collaborate with pharmaceutical partners and communicate methods and results. This is a full-time hybrid role based in Hinxton, UK. The advert gives a closing date of 11 October 2026 at 23:59 CET.

This webinar explains how researchers can retrieve and analyse protein information using UniProt. It demonstrates advanced queries, BLAST searches, peptide searches, and multiple-sequence alignments, including how to navigate outputs and use functional annotations to interpret them. It also discusses how identifiers, ontologies, and controlled vocabularies organize biological knowledge, and how identifier mapping connects resources. The session is suitable for scientists at any career stage who want to use UniProt or extend their existing skills; undergraduate-level biology knowledge is helpful.

This webinar examines reconstruction and use of marine metagenome-assembled genomes. The first part introduces the Ocean Microbiomics Database as a standardized resource for prokaryotic genome-resolved analysis, including co-abundance-based reconstruction, contextual metadata, and relationships between ecological patterns and microbial genomes. The second part considers why eukaryotic genomes are harder to recover: their complexity, low abundance, and limited markers and reference sequences complicate assembly and classification. Participants will compare reconstruction approaches, explore the database, and consider tools and steps for recovering eukaryotic genomes. The session serves academic and industrial researchers developing marine-microbiome applications and infrastructure teams managing samples, data, and discovery resources.

Open biological data resources connect complementary evidence about proteins involved in infection. Using influenza haemagglutinin, this seminar demonstrates sequence and functional annotations in UniProt, three-dimensional cryo-EM maps in EMDB, and experimental and predicted structures in PDBe and the AlphaFold Protein Structure Database. Participants will learn to browse, retrieve and interpret these data and follow connections between the resources. The session also considers how accessible biological data supports infection research and pandemic preparedness. It is aimed at students and researchers in protein biology, structural biology and bioinformatics; basic knowledge of sequence and structure formats is useful.

Interpreting human missense variants requires connecting genomic coordinates with protein sequences, structures and functional evidence. ProtVar integrates annotations and predictions from UniProt, Ensembl, PDBe, Open Targets and AlphaFoldDB, extending variant lookup to discovery across more than 500 million potential missense variants. This seminar demonstrates natural-language searches using diseases, pathways and drug responses, multi-criteria filtering, structural visualisation and data export. Participants will learn to prioritise variants, interpret their structural and functional effects, and retrieve data through web downloads or the REST API. The session serves geneticists, drug-discovery researchers and computational biologists; undergraduate molecular biology and genetics are recommended.