Computational Genomics

Jiaqi Zhang examines how computational models can learn the effects of genetic interventions from single-cell experiments. Such experiments reveal causal relationships, but their high-dimensional measurements are costly to collect and difficult to interpret. The seminar connects identifiable causal representations with a predictive method for previously unseen perturbations. The approach incorporates prior biological knowledge and changes in data distributions to estimate responses at individual-cell resolution. It also uses predictions to guide subsequent experiments. An application identifies and experimentally validates previously unknown T-cell regulators with potential relevance to cancer immunotherapy. The recording follows the original July seminar; the series lists Zhang at MIT, while the recording biography describes her incoming Columbia appointment.

A postdoctoral fellowship at Unicamp’s Institute of Biology integrates genomic and multiomic data to improve genome assembly and functional annotation in bees. Work includes sample preparation, Hi-C, RNA-seq, TSS-seq and ATAC-seq, integration with long-read data, reproducible analysis pipelines and student training. The position is in Campinas, Brazil, with a planned January 2027 start. Applications close on 25 September 2026; the official selection notice explains the required documents and submission method.

EMBL-EBI seeks a Bioinformatics Developer for DECIPHER, a platform supporting rare-disease research and clinical interpretation of genetic variation. The developer will evaluate and integrate genomic and phenotype resources, deploy analysis tools, design database structures and interfaces, investigate data problems and work with clinical and research collaborators. The role is based in Hinxton with hybrid working and may be full time or 80% time. The advert gives a closing date of 8 October 2026 at 23:59 CET.

Investigate immune regulation in sepsis, particularly neuroimmune and interorgan communication, using computational analyses of bulk and single-cell sequencing datasets. The project is funded by FAPESP and is expected to start in November 2026. The advertisement lists 31 October 2026 as its application deadline and states that review starts immediately and continues until the position is filled. Submit a CV, research-interest cover letter and contact details for two references to the investigator listed on the official page.

Jiaqi Zhang examines how computational models can learn the effects of genetic interventions from single-cell experiments. Such experiments reveal causal relationships, but their high-dimensional measurements are costly to collect and difficult to interpret. The seminar connects identifiable causal representations with a predictive method for previously unseen perturbations. The approach incorporates prior biological knowledge and changes in data distributions to estimate responses at individual-cell resolution. It also uses predictions to guide subsequent experiments. An application identifies and experimentally validates previously unknown T-cell regulators with potential relevance to cancer immunotherapy. The recording follows the original July seminar; the series lists Zhang at MIT, while the recording biography describes her incoming Columbia appointment.

EMBL-EBI seeks a Bioinformatics Developer for DECIPHER, a platform supporting rare-disease research and clinical interpretation of genetic variation. The developer will evaluate and integrate genomic and phenotype resources, deploy analysis tools, design database structures and interfaces, investigate data problems and work with clinical and research collaborators. The role is based in Hinxton with hybrid working and may be full time or 80% time. The advert gives a closing date of 8 October 2026 at 23:59 CET.

A postdoctoral fellowship at Unicamp’s Institute of Biology integrates genomic and multiomic data to improve genome assembly and functional annotation in bees. Work includes sample preparation, Hi-C, RNA-seq, TSS-seq and ATAC-seq, integration with long-read data, reproducible analysis pipelines and student training. The position is in Campinas, Brazil, with a planned January 2027 start. Applications close on 25 September 2026; the official selection notice explains the required documents and submission method.

Investigate immune regulation in sepsis, particularly neuroimmune and interorgan communication, using computational analyses of bulk and single-cell sequencing datasets. The project is funded by FAPESP and is expected to start in November 2026. The advertisement lists 31 October 2026 as its application deadline and states that review starts immediately and continues until the position is filled. Submit a CV, research-interest cover letter and contact details for two references to the investigator listed on the official page.