Epigenetics

Matthew J. Girgenti discusses how research on individual brain cells and the three-dimensional organization of DNA is changing the biological understanding of post-traumatic stress disorder. The seminar examines how these approaches reveal trauma-associated brain changes and identify possible targets for more effective, personalized treatments. Girgenti is a neuroscientist in Yale School of Medicine’s Department of Psychiatry. Jeffrey Borenstein moderates this Meet the Scientist session. Online via the BBRF Zoom webinar. Tuesday 13 October 2026, 14:00 EDT (America/New_York; UTC−4). Follow Register Today on the organizer’s event page to the event-specific Zoom form. Advance registration is available to researchers, students, healthcare providers, mental-health organizations, patients and family members.

This EMBO-EMBL symposium connects fundamental mechanisms of DNA replication and genome maintenance with human health and disease. Researchers from molecular biology, genetics, chromatin, replication stress and genome stability meet in Heidelberg and online for talks, discussion and scientific exchange.

This EMBO | EMBL Symposium brings cancer researchers together to examine how tumours spread and resist treatment. Topics include circulating and metastasis-initiating cells, invasion, epigenetic regulation, dormancy, cellular plasticity, immune escape and the tumour microenvironment. The programme connects biological mechanisms with imaging, single-cell and spatial profiling, computational analysis and disease models. The event runs from 10 to 13 November 2026 at the EMBL Advanced Training Centre in Heidelberg, with virtual participation available. Abstract submissions are closed. On-site registration closes on 29 September; virtual registration remains available until 3 November. Registration fees and the two booking routes are listed on the organizer page.

Marcus Buggert’s group at the Centre for Infectious Medicine develops mRNA-based, CD19-directed CAR T cells for chronic lymphocytic leukaemia. The project uses electroporation and targeted lipid nanoparticles to generate transient CAR expression and examines how disease stage, treatment and T-cell differentiation affect killing of malignant B cells. Work combines primary human cells and patient samples, functional co-cultures, high-parameter flow cytometry and live-cell imaging to study killing kinetics, serial killing and repeated mRNA delivery. Phenotypic, transcriptional and epigenetic analyses will identify mechanisms limiting cytotoxicity and routes to improve receptor availability and function. This full-time postdoctoral appointment is based in Flemingsberg; applications through Varbi close on 6 October 2026.

NIDA supports animal genomics research that explains genetic and epigenetic contributions to substance-use disorders and addiction-related phenotypes. Work may integrate molecular measurements, neural circuits, behaviour and computational methods to identify mechanisms and useful experimental resources. This U01 cooperative agreement permits projects lasting up to five years, with budgets based on the proposed work rather than a stated award cap. The next application deadline is 11 February 2027 at 5 p.m. in the applicant organisation’s local time. Clinical trials are not allowed.

Marcus Buggert’s group at the Centre for Infectious Medicine develops mRNA-based, CD19-directed CAR T cells for chronic lymphocytic leukaemia. The project uses electroporation and targeted lipid nanoparticles to generate transient CAR expression and examines how disease stage, treatment and T-cell differentiation affect killing of malignant B cells. Work combines primary human cells and patient samples, functional co-cultures, high-parameter flow cytometry and live-cell imaging to study killing kinetics, serial killing and repeated mRNA delivery. Phenotypic, transcriptional and epigenetic analyses will identify mechanisms limiting cytotoxicity and routes to improve receptor availability and function. This full-time postdoctoral appointment is based in Flemingsberg; applications through Varbi close on 6 October 2026.

Investigate the mechanisms of cellular rejuvenation and resilience through multidisciplinary experimental research. Develop project-specific methods, contribute to collaborations and publications, and help train researchers and graduate students. Relevant areas include epigenetics, metabolism, stem cells, single-cell analysis, functional screening and gene delivery. Multiple scientist levels are available, with advertised salary bands spanning USD 116,450–247,000 depending on level. Applications are currently open.

NIDA supports animal genomics research that explains genetic and epigenetic contributions to substance-use disorders and addiction-related phenotypes. Work may integrate molecular measurements, neural circuits, behaviour and computational methods to identify mechanisms and useful experimental resources. This U01 cooperative agreement permits projects lasting up to five years, with budgets based on the proposed work rather than a stated award cap. The next application deadline is 11 February 2027 at 5 p.m. in the applicant organisation’s local time. Clinical trials are not allowed.

Shiv Grewal discusses how chromatin and epigenetic mechanisms establish, maintain, and transmit genome states beyond the DNA sequence itself. This NIH Wednesday Afternoon Lecture Series event is offered in person and through NIH VideoCast.