Epigenetic changes

…somatic mosaicism, repeat expansions, epigenetic changes and microRNA regulation. It relates biological and technical detection limits to neuronal excitability, clinical heterogeneity and treatment resistance. Thematic presentations and an interactive panel address multi-omics study design, clinical phenotyping, biomarkers and therapeutic development, connecting molecular mechanisms to precision medicine and surgical decisions. Sunday 6 December, 08:30

…then fades, before discussing whether epigenetic changes and jumping genes help explain why larger dogs age more quickly.

…and environmentally influenced epigenetic changes provide possible molecular mechanisms.

Metal exposure is an intriguing potential culprit in the cause of sporadic amyotrophic lateral sclerosis (ALS). Lead (Pb), mercury (Hg), cadmium (Cd) and arsenic (As) are singled out among the ten chemicals of major public health concern by the World Health Organisation. There are numerous case reports and case-control studies linking those metals to an ALS phenotype. Additionally, some studies have demonstrated higher levels of these metals in the blood, cerebrospinal fluid, urine, or spinal cords of patients with ALS compared to controls. Recently, it has been proposed that the interaction b

Glioblastoma, highly aggressive neoplasms, deliver a devastating diagnosis and induce severe symptoms, notably sleep disturbances. Disrupted sleep triggers systemic pro-tumor effects in various cancers. Our research explores the pro-tumor impact of disturbed sleep and potential pathophysiological effects of the brain lesion on sleep ability in our patients, and as indicated by the available literature. To assess sleep quality of patients with neuroradiologically proven brain tumors, participants completed The Pittsburgh Sleep Quality Index questionnaire. After obtaining the pathological diagno

…may be partially explained by epigenetic changes induced by hormone signaling transmitted to the germ cells. The glucocorticoid receptor (GR) is a transcription factor that constitutes a key player in stress signaling involving corticoids. Surprisingly, GR is present in the transcriptionally silent sperm, implying a paternal role in fertilization or early embryos. Here, we investigate the role of GR in mediating stress-induced epigenetic changes in m