Chromatin

This conference examines how chromatin and epigenetic regulation shape gene expression, development and disease. It covers DNA methylation, histone and RNA modifications, non-coding RNAs, heterochromatin, nucleosome structure and nuclear architecture. Researchers will connect transcriptional control with developmental processes and disease mechanisms, using single-cell genomics and advanced microscopy alongside molecular approaches. The programme also considers how ageing, environmental exposures and lifestyle influence epigenetic states. The meeting brings together researchers working across

…cellular development, evolution, chromatin and collective behaviour away from equilibrium.

…of origin firing across tissues, chromatin and epigenome maintenance, chromosome organisation, replication-fork protection and repair, and the consequences of replication stress for development, ageing and cancer. The programme links mechanistic advances to cancer biology and possible therapeutic approaches. All programme times are Europe/Berlin. Opening remarks on 20 October begin at 13:30, followed by the keynote at 13:45

Shiv Grewal discusses how chromatin and epigenetic mechanisms establish, maintain, and transmit genome states beyond the DNA sequence itself. This NIH Wednesday Afternoon Lecture Series event is offered in person and through NIH VideoCast.

The seventeenth EMBL conference on transcriptional regulation covers polymerase function, chromatin modification and remodeling, epigenetic inheritance, genome topology, condensates, development, disease, and quantitative methods.

Developmental and Epileptic Encephalopathy 9 (DEE9) is a debilitating neurological condition with no effective cure characterized by epilepsy, intellectual disability and autism. DEE9 is due to mutations in the X-chromosome gene PCDH19 that encodes protocadherin-19 (PCDH19), a cell adhesion molecule. We recently reported that PCDH19 undergoes an activity-dependent proteolytic cleavage that generates a cytosolic C-terminal fragment (CTF), which goes in the nucleus and regulates the expression of a subset of immediate early genes in primary hippocampal neurons.The aim of this project is to inves

Three intimately related dimensions of the mammalian genome—linear DNA sequence, gene transcription, and 3D genome architecture—are crucial for the development of nervous systems. Changes in the linear genome (e.g., de novo mutations), transcriptome, and 3D genome structure lead to debilitating neurodevelopmental disorders, such as autism and schizophrenia. However, current technologies and data are severely limited: (1) 3D genome structures of single brain cells have not been solved; (2) little is known about the dynamics of single-cell transcriptome and 3D genome after birth; (3) true de nov

…activities are facilitated by DNA/chromatin-binding protein motors called SMC complexes. Each of these motors can perform a unique activity known as “loop extrusion,” in which the motor binds the DNA/chromatin polymer, reels i