Topic: gene regulation

Transposable-element biology and evolution are connected with practical bioinformatic methods for identifying and analysing repetitive DNA. Participants examine how these mobile sequences influence genome structure, gene regulation and epigenetic states, and why their rapid evolution complicates computational annotation. The programme combines conceptual instruction with analysis exercises across the published five-day schedule. Teaching runs online from 14:00 to 19:00 Berlin time. The listed course package costs €480.

Study gene regulation by processing and integrating RNA-seq, ATAC-seq, MNase-seq, ChIP-seq and Hi-C measurements. The five workshop days cover expression analysis, chromatin accessibility, chromatin composition, three-dimensional genome interactions and multi-omics integration. Practical work includes quality control, alignment, differential expression, peak and motif analysis, and visualisation of genomic contacts. Reproducible Linux and R notebooks connect assay design to biological interpretation. Live online, 22–26 February, 13:00–19:00 Europe/Berlin (CET). Fee €480. Participants need a b

Develop multimodal foundation-model methods for gene regulation using modern deep learning, Bayesian inference and causal modelling. Work at the interface of computational research and large-scale biological data.

Develop sequence-based deep-learning models of gene regulation and aging. Research predicts gene expression and chromatin accessibility from DNA, interprets genetic variation and connects model predictions with experiments, causal mechanisms and possible intervention points.

The Laboratory for Functional Genomics and Gene Regulation at VIB–KU Leuven seeks a postdoctoral researcher studying cancer-cell plasticity, using pancreatic ductal adenocarcinoma as the main model. The project investigates how gene regulation permits changes in cellular identity, environmental adaptation and treatment evasion. Functional genomics is combined with advanced cancer models and access to single-cell and spatial technologies, imaging, metabolomics and animal research. The researcher will take ownership of emerging projects and help develop experimental approaches in a growing labor

Investigate biological diversity through RNA and translation research. The postdoctoral work includes ribosome profiling of natural yeast strains and development of methods for studying gene regulation.

Convergence Seminar by Alexis Battle, PhD (Wu and Zhang Professor of Biomedical Engineering and Computer Science, Johns Hopkins University), on computational and machine-learning approaches for analyzing how genetic variation impacts gene regulation and disease, including noncoding sequences and rare variants.

This lecture examines genetic control of tail length using variation between deer-mouse populations and targeted experiments. It considers multiple quantitative-trait loci, the possible role of Hoxd13 expression and evidence from altered Hox13 activity. Vertebral development provides a case study of how changes in gene regulation can produce evolutionary changes in body form.

This lecture examines how genetic predisposition interacts with environmental exposure in disease. It reviews methods for detecting these interactions, the role of large biobanks and examples including obesity. Gene regulation and environmentally influenced epigenetic changes provide possible molecular mechanisms.

This lecture examines how regulatory DNA contacts its target genes through both CTCF-dependent and other mechanisms. It then considers diseases caused by disrupted enhancer function, ranging from missing elements to genomic rearrangements that alter regulatory contacts. Transposable elements are discussed as contributors to the evolution of gene regulation.

In the third of this year’s Brain Prize webinars, Oscar Marin (King's College London, UK), Leslie Griffith (Brandeis University, USA), and Kesley Martin (Simons Foundation, USA) will present their work on shaping connections through remote gene regulation. Each speaker will present for 25 minutes, and the webinar will conclude with an open discussion. The webinar will be moderated by the winners of the 2023 Brain Prize, Michael Greenberg, Erin Schuman and Christine Holt.

Although memories are largely thought to be encoded in the brain via modifications to synaptic weights, technical and conceptual issues with this view (e.g., the large disparity between the time scale of synaptic turnover and long-term human memories) lead some to hypothesize that intracellular processes like gene regulation and post-translational modifications support complementary memory storage mechanisms. While this possibility is appealing, it lacks the mature theoretical apparatus associated with canonical theories of neural network memory storage and recall. To ameliorate this issue, we

Aims: Nuclear pore complex proteins (Nups) play critical roles in cell type-specific gene regulation by orchestrating lineage specification and maintenance of cellular state. However, their roles in adult brain remain largely elusive, especially in post-mitotic functional neurons. Accurate spatio-temporal regulation of neuronal gene programs is vital for neuronal plasticity and ultimately for learning and memory. We hypothesize that Nups play critical roles in neuronal plasticity and cognition through gene regulation. Methods: To address the importance of Nups for cognition and memory, we cond