Topic: transcription

This EMBO–EMBL symposium examines how messenger and non-coding RNAs transmit and regulate genetic information. It connects transcription, processing and modification, export and localisation, surveillance and decay, translation, and coupling between these processes. Sessions cover co-transcriptional and co-translational biology, RNA processing, RNP condensates, structure and regulation, and pathogens and therapeutics. The programme uses Europe/Berlin time: opening remarks on 13 October at 20:00, followed by the first keynote at 20:15; sessions begin at 09:00 on 14–15 October and 10:00 on 16 O

Study cellular mechanisms of Parkinson’s disease in the Jan Lab. Research integrates patient genetics, genomics and biomarkers with cellular and animal models, functional-genomic screening and measurements of morphology and transcription. Fellows develop independent projects during a three-year programme with a possible fourth year.

Single-cell measurements of mRNA copy numbers inform our understanding of stochastic gene expression, but these measurements coarse-grain over the individual copies of the gene, where transcription and its regulation take place stochastically. We recently combined single-molecule quantification of mRNA and gene loci to measure the transcriptional activity of an endogenous gene in individual Escherichia coli bacteria. When interpreted using a theoretical model for mRNA dynamics, the single-cell data allowed us to obtain the probabilistic rates of promoter switching, transcription initiation and