Cryo-electron microscopy

…biology, biochemical reconstitution, cryo-electron microscopy sample preparation and imaging, single-particle structure determination using Relion and Cryosparc, and molecular model building. Work includes coordinating collaborations, preparing manuscripts and figures, contributing to grants, maintaining laboratory resources and mentoring trainees. The published salary range is USD 79,400–119,500, with possible additional

…NMR, ion-mobility mass spectrometry, cryo-electron microscopy and crystallography, with research on protein complexes, membrane interactions, RNA-binding proteins and host–parasite recognition. Short talks selected from abstracts and poster presentations complement invited lectures. Organized by Simon Newstead and Rachael Wilkinson. The meeting runs on 11 December, with registration at 10:30 and close at 18:15. Registration costs GBP 80 including refreshments, lunch

…structures from crystallography and cryo-electron microscopy. Topics include generative models, free-energy calculations, ligand rigidification and physicochemical optimisation for protein-interaction inhibitors, PROTACs, molecular glues and antibody–drug-conjugate payloads. Intended for medicinal and computational chemists, structural biologists, biophysicists and NMR specialists; prior conformational-design experience is unnecessary. Or

…Research approaches include cryo-electron microscopy, molecular phylogenetics and sequencing-based functional analysis.

This Keystone Symposium brings structural and cellular biologists together to integrate cryo-electron microscopy, super-resolution and multiscale imaging, data science, computational modeling and deep learning. The programme connects molecular structure to tissue-level function and includes in-person, livestream and on-demand participation.

Cannabis activates the cannabinoid receptor 1 (CB1), which elicits analgesic and emotion regulation benefits; nevertheless, it is accompanied by adverse effects that impede its medical applications. The selective activation or inhibition of G-protein or β-arrestin signaling cascades could potentially generate drugs with a more precise targeting profile and fewer adverse effects, ultimately expanding the therapeutic range. However, the lack of understanding of the mechanism of β-arrestin-1 (βarr1) coupling and signaling bias has hindered drug development targeting CB1. Here, we present the high

Heat shock protein 60 (Hsp60) functions as a molecular chaperone, playing a vital role in maintaining protein homeostasis by regulating protein folding and preventing protein aggregation. Levels of heat shock proteins increase in response to oxidative stress and mitochondrial damage, both of which are symptoms commonly associated with various forms of epilepsy. Hsp60 levels are increased in the plasma of patients with temporal lobe epilepsy (TLE). It is crucial to understand what conformations and functions Hsp60 obtains within its folding cycle to determine Hsp60’s role in seizure response. F