Topic: opioid use disorder

Withdrawal from opioids is associated with a highly aversive affective state, and avoidance of this state is a main reason people with opioid use disorder continue to use or relapse to opioids. Activity in the ventral pallidum (VP) is necessary for opioid relapse after withdrawal. Recent studies from our group and others have shown that glutamatergic VP neurons (VPGlu) constitute a unique subpopulation of VP neurons, and that VPGlu activity constrains reward seeking, particularly in decision-making tasks where negative consequences are associated with choosing a reward. However, how self-admin