Chromatin accessibility

…days cover expression analysis, chromatin accessibility, chromatin composition, three-dimensional genome interactions and multi-omics integration. Practical work includes quality control, alignment, differential expression, peak and motif analysis, and visualisation of genomic contacts. Reproducible Linux and R notebooks connect assay design to biological interpretation. Live online, 22–26 February, 13:00–19:00 Europe/Berlin (CET). Fee €480. Participants need a b

…Research predicts gene expression and chromatin accessibility from DNA, interprets genetic variation and connects model predictions with experiments, causal mechanisms and possible intervention points.

…epigenetic profiles and higher-order chromatin interactions that depend on SATB2 in cortical pyramidal neurons of the mouse by integrating high-resolution, multidimensional datasets from Satb2 conditional knockout (cKO) and floxed mice. With remarkable specificity, SATB2-me

…changes in the levels of H3K27ac and chromatin accessibility accordingly with the redistribution and modification of the epigenetic c

…we assessed gene expression and chromatin accessibility in the posterior bed nucleus of the st

Rhythmic changes in sex hormone levels across the ovarian cycle exert powerful effects on the brain and behavior, and confer female-specific risks for neuropsychiatric conditions. In this talk, Dr. Kundakovic will discuss the role of fluctuating ovarian hormones as a critical biological factor contributing to the increased depression and anxiety risk in women. Cycling ovarian hormones drive brain and behavioral plasticity in both humans and rodents, and the talk will focus on animal studies in Dr. Kundakovic’s lab that are revealing the molecular and receptor mechanisms that underlie this fema