arterial stiffness
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Taking the pulse of ageing: the role of cerebrovascular risk factors in ageing and dementia
Cerebrovascular support is critical for healthy cognitive ageing. Reduced cerebral blood flow in ageing is caused, among other things, by hypertension, arteriosclerosis (i.e. stiffening of the arteries) and plaque formation. Arterial stiffness is predictive of cognitive decline, is a critical risk factor for cerebrovascular accidents, and has been linked to heightened risks for Alzheimer’s Disease and other forms of dementia. The elasticity of cerebral arteries is influenced by lifestyle factors, including cardiorespiratory fitness. Monica will discuss data obtained in their laboratory with new noninvasive measures of cerebrovascular health (pulse-DOT, a diffuse optical tomographic method for studying cerebral arteriosclerosis), in conjunction with structural and functional brain measures and cognitive assessments. These findings support a model in which localised changes in arteriosclerosis lead to specific profiles of structural, functional, and cognitive declines, paving a way to individualised interventions.
QUANTIFICATION OF INTRACRANIAL ARTERIAL STIFFNESS USING DYNAMIC INFLOW MAGNITUDE CONTRAST MRI: A FEASIBILITY STUDY IN ACUTE STROKE/TIA PATIENTS AND ITS RELATION TO SMALL VESSEL DISEASE
FENS Forum 2026
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