auditory processing

Direction selectivity in hearing: monaural phase sensitivity in octopus neurons

The processing of temporal sound features is fundamental to hearing, and the auditory system displays a plethora of specializations, at many levels, to enable such processing. Octopus neurons are the most extreme temporally-specialized cells in the auditory (and perhaps entire) brain, which make them intriguing but also difficult to study. Notwithstanding the scant physiological data, these neurons have been a favorite cell type of modeling studies which have proposed that octopus cells have critical roles in pitch and speech perception. We used a range of in vivo recording and labeling methods to examine the hypothesis that tonotopic ordering of cochlear afferents combines with dendritic delays to compensate for cochlear delay - which would explain the highly entrained responses of octopus cells to sound transients. Unexpectedly, the experiments revealed that these neurons have marked selectivity to the direction of fast frequency glides, which is tied in a surprising way to intrinsic membrane properties and subthreshold events. The data suggest that octopus cells have a role in temporal comparisons across frequency and may play a role in auditory scene analysis.

Pulvinar and striatal circuits for auditory processing and behaviors

Activation of basal forebrain parvalbumin neurons exerts frequency dependent effects on auditory processing and behavior in the rat

Altered topographic population activity in the auditory cortex of an auditory processing-impaired mouse model

Developmental overexpansion of cerebral cortex in mice negatively affects auditory processing in adulthood

How emotional states shape perception: A mechanistic understanding of state dependent auditory processing

Functional maps of the mouse prefrontal cortex during auditory processing: high-density recordings across prefrontal layers, subregions, and functions

Human cortical auditory processing of naturalistic speech with simulated hearing loss: A data-driven fMRI approach

Auditory processing deficits in a rat model of Down syndrome

FENS Forum 2024

Breakdown of auditory processing hierarchy in human sleep

FENS Forum 2024