TopicNeuroscience

autoimmune

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27ePosters

2Seminars

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The immunopathogenesis of autoimmune seizure disorders

Adam Handel

Oxford University

Mar 27, 2024

Immune-mediated mechanisms are increasingly recognised as a cause of epilepsy even in the absence of an immune response against a specifical neuronal antigen. In some cases, these autoimmune processes are clearly pathogenic, for example acute seizures in autoimmune encephalitis, whereas in others this is less clear, for example autoimmune-associated epilepsy. Recent research has provided novel insights into the clinical, paraclinical and immunopathogenetic mechanisms in these conditions. I will provide an overview of clinical and paraclinical features of immune-associated seizures. Furthermore, I will describe specific immunopathogenic examples implicating lymphoid follicular autoimmunisation and intrathecal B cells in these conditions. These insights into immunopathogenesis may help to explain the role of current and immunotherapies in these conditions.

SeminarNeuroscience

autoimmune

Latest

The immunopathogenesis of autoimmune seizure disorders

Autoimmune encephalitis

ACCELERATED BRAIN AGING IN AUTOIMMUNE ENCEPHALITIS BASED ON BRAIN-PREDICTED AGE DIFFERENCE

DISTINCT CSF-COMPARTMENTALIZED ANTIBODY FUCTIONALITIES DURING HSV1 INFECTION ASSOCIATE WITH SITE OF INFECTION, DISEASE SEVERITY AND PREDICT POST-HERPES AUTOIMMUNE ENCEPHALITIS

SYSTEMIC INFLAMMATION AND REPRODUCTIVE DISORDERS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

MONOAMINERGIC AND TRYPTOPHAN PATHWAY DYSREGULATION UNDERLIES EARLY ANHEDONIC-LIKE BEHAVIOR IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

IGLON5, THE CELL-ADHESION MOLECULE IMPLICATED IN ANTI-IGLON5 AUTOIMMUNE TAUOPATHY, INTERACTS WITH NEUROLIGIN-1 TO LIMIT EXCITATORY SYNAPSE FORMATION

AGING MODULATES DISEASE PROGRESSION, MYELOID CELL RESPONSES, AND TREATMENT RESPONSE IN THE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MODEL

EFFECTS OF AUTOIMMUNE ANTIBODIES ON NETWORK FUNCTION IN IPSC-DERIVED NEURONAL CULTURES

PATIENT-DERIVED CSF FROM A CASE OF ANTI-DAGLA AUTOIMMUNE ENCEPHALITIS INDUCES SYNAPTIC DYSFUNCTION

AUTOIMMUNE NEUROINFLAMMATION’S FOOTPRINT ON NEURONS: A BRAIN-WIDE SIGNATURE UNVEILED

Synaptic network dysfunction and increased intrinsic neuronal excitability in GluA2 autoimmune encephalitis

Validation of IHC markers antibody panel in rat Experimental Autoimmune Encephalomyelitis (EAE) model of multiple sclerosis

Activation of complement C3 in the course of rat experimental autoimmune encephalomyelitis

Cannabinoid CB1 receptors in oligodendrocytes: Modulation of energy metabolism and autoimmune demyelination

Elucidating neuronal activity patterns in autoimmune neuroinflammation: A brain-wide approach

Ex-vivo and in-vivo analysis of hippocampal pathology in a murine model of anti-GABAB autoimmune encephalitis

Meningeal neural progenitors respond to central nervous system autoimmune disease and interact with immune cells

Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis

Unveiling cortical microvascular dysfunction and neurodegeneration mechanisms in experimental autoimmune encephalomyelitis

Astrocytic S100B protein in experimental autoimmune encephalomyelitis processes

Age-dependent role of NMDA receptors in experimental autoimmune encephalomyelitis

Calcium imaging to determine the pathogenic effects of NMDAR antibodies in autoimmune encephalitis

Genetic predisposition in autoimmune encephalitis associated with autoantibodies against glutamic acid decarboxylase

Impact of the new pomegranate-peels extract formulation in mice suffering from experimental autoimmune encephalomyelitis

Osteopontin is a biomarker for experimental autoimmune encephalomyelitis and uveitis

Pathogenic effects of GABAB receptor antibodies from patients with autoimmune encephalitis on neuronal signaling and network excitability

Pathogenic effects of GABAB receptor antibodies from patients with autoimmune encephalitis on synaptic structure and memory

Preventive exercise counteracts glutamatergic transmission defects in the striatum of mice with experimental autoimmune encephalomyelitis