TopicNeuroscience

autoimmune

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20Total items

18ePosters

2Seminars

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SeminarNeuroscienceRecording

The immunopathogenesis of autoimmune seizure disorders

Adam Handel

Oxford University

Mar 27, 2024

Immune-mediated mechanisms are increasingly recognised as a cause of epilepsy even in the absence of an immune response against a specifical neuronal antigen. In some cases, these autoimmune processes are clearly pathogenic, for example acute seizures in autoimmune encephalitis, whereas in others this is less clear, for example autoimmune-associated epilepsy. Recent research has provided novel insights into the clinical, paraclinical and immunopathogenetic mechanisms in these conditions. I will provide an overview of clinical and paraclinical features of immune-associated seizures. Furthermore, I will describe specific immunopathogenic examples implicating lymphoid follicular autoimmunisation and intrathecal B cells in these conditions. These insights into immunopathogenesis may help to explain the role of current and immunotherapies in these conditions.

SeminarNeuroscience

autoimmune

Latest

The immunopathogenesis of autoimmune seizure disorders

Autoimmune encephalitis

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