autoimmune encephalitis

The immunopathogenesis of autoimmune seizure disorders

Immune-mediated mechanisms are increasingly recognised as a cause of epilepsy even in the absence of an immune response against a specifical neuronal antigen. In some cases, these autoimmune processes are clearly pathogenic, for example acute seizures in autoimmune encephalitis, whereas in others this is less clear, for example autoimmune-associated epilepsy. Recent research has provided novel insights into the clinical, paraclinical and immunopathogenetic mechanisms in these conditions. I will provide an overview of clinical and paraclinical features of immune-associated seizures. Furthermore, I will describe specific immunopathogenic examples implicating lymphoid follicular autoimmunisation and intrathecal B cells in these conditions. These insights into immunopathogenesis may help to explain the role of current and immunotherapies in these conditions.

Autoimmune encephalitis

Calcium imaging to determine the pathogenic effects of NMDAR antibodies in autoimmune encephalitis

Genetic predisposition in autoimmune encephalitis associated with autoantibodies against glutamic acid decarboxylase

Pathogenic effects of GABAB receptor antibodies from patients with autoimmune encephalitis on neuronal signaling and network excitability

Pathogenic effects of GABAB receptor antibodies from patients with autoimmune encephalitis on synaptic structure and memory

Synaptic network dysfunction and increased intrinsic neuronal excitability in GluA2 autoimmune encephalitis

Ex-vivo and in-vivo analysis of hippocampal pathology in a murine model of anti-GABAB autoimmune encephalitis

FENS Forum 2024

Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis

FENS Forum 2024