autoimmune encephalitis

The immunopathogenesis of autoimmune seizure disorders

Immune-mediated mechanisms are increasingly recognised as a cause of epilepsy even in the absence of an immune response against a specifical neuronal antigen. In some cases, these autoimmune processes are clearly pathogenic, for example acute seizures in autoimmune encephalitis, whereas in others this is less clear, for example autoimmune-associated epilepsy. Recent research has provided novel insights into the clinical, paraclinical and immunopathogenetic mechanisms in these conditions. I will provide an overview of clinical and paraclinical features of immune-associated seizures. Furthermore, I will describe specific immunopathogenic examples implicating lymphoid follicular autoimmunisation and intrathecal B cells in these conditions. These insights into immunopathogenesis may help to explain the role of current and immunotherapies in these conditions.

Autoimmune encephalitis

DISTINCT CSF-COMPARTMENTALIZED ANTIBODY FUCTIONALITIES DURING HSV1 INFECTION ASSOCIATE WITH SITE OF INFECTION, DISEASE SEVERITY AND PREDICT POST-HERPES AUTOIMMUNE ENCEPHALITIS

FENS Forum 2026

ACCELERATED BRAIN AGING IN AUTOIMMUNE ENCEPHALITIS BASED ON BRAIN-PREDICTED AGE DIFFERENCE

FENS Forum 2026

PATIENT-DERIVED CSF FROM A CASE OF ANTI-DAGLA AUTOIMMUNE ENCEPHALITIS INDUCES SYNAPTIC DYSFUNCTION

FENS Forum 2026

Pathogenic effects of GABAB receptor antibodies from patients with autoimmune encephalitis on synaptic structure and memory

Calcium imaging to determine the pathogenic effects of NMDAR antibodies in autoimmune encephalitis

Ex-vivo and in-vivo analysis of hippocampal pathology in a murine model of anti-GABAB autoimmune encephalitis

FENS Forum 2024

Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis

FENS Forum 2024

Synaptic network dysfunction and increased intrinsic neuronal excitability in GluA2 autoimmune encephalitis

Genetic predisposition in autoimmune encephalitis associated with autoantibodies against glutamic acid decarboxylase

Pathogenic effects of GABAB receptor antibodies from patients with autoimmune encephalitis on neuronal signaling and network excitability