bipolar disorder

Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains

Linking GWAS to pharmacological treatments for psychiatric disorders

Genome-wide association studies (GWAS) have identified multiple disease-associated genetic variations across different psychiatric disorders raising the question of how these genetic variants relate to the corresponding pharmacological treatments. In this talk, I will outline our work investigating whether functional information from a range of open bioinformatics datasets such as protein interaction network (PPI), brain eQTL, and gene expression pattern across the brain can uncover the relationship between GWAS-identified genetic variation and the genes targeted by current drugs for psychiatric disorders. Focusing on four psychiatric disorders---ADHD, bipolar disorder, schizophrenia, and major depressive disorder---we assess relationships between the gene targets of drug treatments and GWAS hits and show that while incorporating information derived from functional bioinformatics data, such as the PPI network and spatial gene expression, can reveal links for bipolar disorder, the overall correspondence between treatment targets and GWAS-implicated genes in psychiatric disorders rarely exceeds null expectations. This relatively low degree of correspondence across modalities suggests that the genetic mechanisms driving the risk for psychiatric disorders may be distinct from the pathophysiological mechanisms used for targeting symptom manifestations through pharmacological treatments and that novel approaches for understanding and treating psychiatric disorders may be required.

Sleep-wake variations of electrodermal activity in bipolar disorder

FENS Forum 2024

Alterations in microglia and their LAG3 checkpoint expression in the hippocampus of suicidal bipolar disorder patients

Assessing positive and negative valence systems to refine animal models of bipolar disorders: the example of GBR 12909-induced manic phenotype

Cytoskeleton regulation as possible critical hub of lithium response in patients with bipolar disorder

Hyperexcitability and Wnt/β-catenin signaling pathway in neurons derived from bipolar disorder patients

Investigating brain-cognition associations in Bipolar Disorder using Canonical Correlation Analysis

The role of calcium signaling during neural development in bipolar disorder (BPD)

Speech signal analysis to classify Bipolar Disorder symptoms in ADHD patients

Development of a test battery for social behavior and assessing a rat model for bipolar disorder

FENS Forum 2024

Fecal microbiota transplantation from individual with bipolar disorder and healthy control elicits distinct behaviors and metabolite profiles in mice

FENS Forum 2024

PDE5A upregulation in bipolar disorder: Insights from single-nucleus RNA sequencing of human basal ganglia

FENS Forum 2024