cell reprogramming
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Genetic and epigenetic underpinnings of neurodegenerative disorders
Pluripotent cells, including embryonic stem (ES) and induced pluripotent stem (iPS) cells, are used to investigate the genetic and epigenetic underpinnings of human diseases such as Parkinson’s, Alzheimer’s, autism, and cancer. Mechanisms of somatic cell reprogramming to an embryonic pluripotent state are explored, utilizing patient-specific pluripotent cells to model and analyze neurodegenerative diseases.
Analysis and manipulation of facilitators and barriers of cell identity reprogramming
Innovative models for amyotrophic lateral sclerosis research: Dermal fibroblasts and direct cell reprogramming
FENS Forum 2024
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