cellular diversity

Fate and freedom in developing neocortical circuits

During brain development, neurons are born in specialized niches and migrate to target regions where they assemble to form the circuits that underlie mammalian behaviour. During their journey, neurons follow cell-intrinsic, genetic programs transmitted by their mother cells but also environmental cues, which together drive their maturation. Here, focusing on the neocortex, I will discuss recent findings from our laboratory in which we untangle and manipulate the programs at play in progenitors and their daughter neurons to better understand the emergence of cellular diversity in the developing brain.