cholinergic neurons
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Neuromodulation of sleep integrity
The arousal construct underlies a spectrum of behaviors that include sleep, exploration, feeding, sexual activity and adaptive stress. Pathological arousal conditions include stress, anxiety disorders, and addiction. The dynamics between arousal state transitions are modulated by norepinephrine neurons in the locus coeruleus, histaminergic neurons in the hypothalamus, dopaminergic neurons in the mesencephalon and cholinergic neurons in the basal forebrain. The hypocretin/orexin system in the lateral hypothalamus I will also present a new mechanism underlying sleep fragmentation during aging. Hcrt neurons are hyperexcitable in aged mice. We identify a potassium conductance known as the M-current, as a critical player in maintaining excitability of Hcrt neurons. Genetic disruption of KCNQ channels in Hcrt neurons of young animals results in sleep fragmentation. In contrast, treatment of aged animals with a KCNQ channel opener restores sleep/wake architecture. These data point to multiple circuits modulating sleep integrity across lifespan.
EFFECTS OF SELECTIVE STIMULATION OF MEDIAL SEPTAL CHOLINERGIC NEURONS ON ALZHEIMER’S DISEASE PATHOLOGY IN A TRANSGENIC MOUSE MODEL
FENS Forum 2026
LATERAL SEPTAL CHOLINERGIC NEURONS REPRESENT AVERSIVE STIMULI AND MEDIATE AVOIDANCE BEHAVIOR
FENS Forum 2026
LATE-ONSET CHRONIC ALCOHOL CONSUMPTION EFFECTS ON THE TOTAL NUMBER OF CHOLINERGIC NEURONS OF THE LATERODORSAL TEGMENTAL NUCLEUS OF THE RAT: AN UNBIASED STEREOLOGICAL STUDY
FENS Forum 2026
In vivo examination of age-dependent changes in the activity of basal forebrain cholinergic neurons during a Pavlovian conditioning task
Effects of chemogenetic inhibition of mesopontine cholinergic neurons on REM sleep and PGO waves in mice
FENS Forum 2024
Anatomical, electrophysiological, and functional characterization of lateral septal cholinergic neurons
FENS Forum 2024
A deep sequencing investigation of mitochondrial DNA damage in cholinergic neurons of the Pedunculopontine Nucleus
FENS Forum 2024
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