cohort study

When to stop immune checkpoint inhibitor for malignant melanoma? Challenges in emulating target trials

Observational data have become a popular source of evidence for causal effects when no randomized controlled trial exists, or to supplement information provided by those. In practice, a wide range of designs and analytical choices exist, and one recent approach relies on the target trial emulation framework. This framework is particularly well suited to mimic what could be obtained in a specific randomized controlled trial, while avoiding time-related selection biases. In this abstract, we present how this framework could be useful to emulate trials in malignant melanoma, and the challenges faced when planning such a study using longitudinal observational data from a cohort study. More specifically, two questions are envisaged: duration of immune checkpoint inhibitors, and trials comparing treatment strategies for BRAF V600-mutant patients (targeted therapy as 1st line, followed by immunotherapy as 2nd line, vs. immunotherapy as 2nd line followed by targeted therapy as 1st line). Using data from 1027 participants to the MELBASE cohort, we detail the results for the emulation of a trial where immune checkpoint inhibitor would be stopped at 6 months vs. continued, in patients in response or with stable disease.

Two pathways to self-harm in adolescence

The behavioural and emotional profiles underlying adolescent self-harm, and its developmental risk factors, are relatively unknown. The authors of this paper aimed to identify sub-groups of young people who self-harm (YPSH) and longitudinal predictors leading to self-harm using the Millennium Cohort Study. (Pre-print: https://www.medrxiv.org/content/10.1101/2020.07.10.20150789v1)

Longitudinal effect of psychiatric medication on suicidal ideation: A prospective cohort study

Network Analysis between Suicide-Related Symptoms and Suicide Attempt Risk in Psychotic Disorder and Mood Disorder: A prospective cohort study

Correlation between neuroprotection in a tauopathy environment following trauma and delayed astrogliosis in a cohort study

FENS Forum 2024

Maternal C-reactive protein is associated with white matter alterations in female offspring: A neuroimaging analysis from the FinnBrain Birth Cohort Study

FENS Forum 2024

Waist circumference and all-cause mortality in Parkinson disease: A nationwide population-based cohort study

FENS Forum 2024