d1 receptors
Latest
Dopaminergic modulation of synaptic plasticity in learning and psychiatric disorders
Transient changes in dopamine activity in response to reward and punishment have been known to regulate reward-related learning. However, the cellular basis that detects the transient dopamine signaling has long been unclear. Using two-photon microscopy and optogenetics, I have shown that transient increases and decreases of dopamine modulate plasticity of dopamine D1 and D2 receptor-expressing cells in the nucleus accumbens, respectively. At the behavioral level, I characterized that these D1 and D2 cells cooperatively tune learning by generalization and discrimination learning. Interestingly, disturbance of the dopamine signaling impaired D2 cell plasticity and discrimination learning, which was analogous to salience misattribution seen in subjects with schizophrenia.
FUNCTIONAL EXPRESSION OF GLUD1 RECEPTORS IN THE HIPPOCAMPAL CA2 FIELD
FENS Forum 2026
D1 receptors in the nucleus accumbens regulate social fear memory processing
FENS Forum 2024
d1 receptors coverage
3 items
Share your knowledge
Know something about d1 receptors? Help the community by contributing seminars, talks, or research.
Contribute content