d2 receptors

Dopaminergic modulation of synaptic plasticity in learning and psychiatric disorders

Transient changes in dopamine activity in response to reward and punishment have been known to regulate reward-related learning. However, the cellular basis that detects the transient dopamine signaling has long been unclear. Using two-photon microscopy and optogenetics, I have shown that transient increases and decreases of dopamine modulate plasticity of dopamine D1 and D2 receptor-expressing cells in the nucleus accumbens, respectively. At the behavioral level, I characterized that these D1 and D2 cells cooperatively tune learning by generalization and discrimination learning. Interestingly, disturbance of the dopamine signaling impaired D2 cell plasticity and discrimination learning, which was analogous to salience misattribution seen in subjects with schizophrenia.

Exploration of learning by dopamine D1 and D2 receptors by a spiking network model of the basal ganglia

COSYNE 2022

Influence of dopamine on theta rhythm: role of D2 receptors in Sst and PV interneurons

Restoration of dopamine D2 receptors in the sensorimotor striatum of D2R knockdown mice selectively ameliorates deficits in motor skill learning

Astrocytes in globus pallidus externa integrate sensory information through dopamine D2 receptors

FENS Forum 2024

MolBoolean staining reveals high proportion of D2 receptors forming A2A-D2 heteromers in striatal neurons of MPTP-lesioned parkinsonian primates

FENS Forum 2024

Unexpected contribution of striatal projection neurons co-expressing dopamine D1 and D2 receptors in balancing motor control

FENS Forum 2024