disease stages

Convergent large-scale network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages

Mathematical models of neurodegenerative diseases

Neurodegenerative diseases such as Alzheimer’s or Parkinson’s are devastating conditions with poorly understood mechanisms and no cure. Yet, a striking feature of these conditions is the characteristic pattern of invasion throughout the brain, leading to well-codified disease stages associated with various cognitive deficits and pathologies. How can we use mathematical modelling to gain insight into this process and, doing so, gain understanding about how the brain works? In this talk, I will show that by linking new mathematical theories to recent progress in imaging, we can unravel some of the universal features associated with dementia and, more generally, brain functions.

Network properties of structural-functional interplay across disease stages in early psychosis (EP): a whole brain model approach

Neuromatch 5