dopamine release
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Light-driven dopamine release in the adult and developing retina
Learning in/about/from the basal ganglia
The basal ganglia are a collection of brain areas that are connected by a variety of synaptic pathways and are a site of significant reward-related dopamine release. These properties suggest a possible role for the basal ganglia in action selection, guided by reinforcement learning. In this talk, I will discuss a framework for how this function might be performed and computational results using an upward mapping to identify putative low-dimensional control ensembles that may be involved in tuning decision policy. I will also present some recent experimental results and theory – related to effects of extracellular ion dynamics -- that run counter to the classical view of basal ganglia pathways and suggest a new interpretation of certain aspects of this framework. For those not so interested in the basal ganglia, I hope that the upward mapping approach and impact of extracellular ion dynamics will nonetheless be of interest!
Mechanisms and Roles of Fast Dopamine Signaling
Dopamine is a neuromodulator that codes information on various time scales. I will discuss recent progress on the identification of fast release mechanisms for dopamine in the mouse striatum. I will present data on triggering mechanisms of dopamine release and evaluate its roles in striatal regulation. In the long-term, our work will allow for a better understanding of the mechanisms and time scales of dopamine coding in health and disease.
Network dynamics in the basal ganglia and possible implications for Parkinson’s disease
The basal ganglia are a collection of brain areas that are connected by a variety of synaptic pathways and are a site of significant reward-related dopamine release. These properties suggest a possible role for the basal ganglia in action selection, guided by reinforcement learning. In this talk, I will discuss a framework for how this function might be performed. I will also present some recent experimental results and theory that call for a re-evaluation of certain aspects of this framework. Next, I will turn to the changes in basal ganglia activity observed to occur with the dopamine depletion associated with Parkinson’s disease. I will discuss some of the potential functional implications of some of these changes and, if time permits, will conclude with some new results that focus on delta oscillations under dopamine depletion.
Dopamine release in the nucleus accumbens core signals perceived saliency
The role of spatiotemporal waves in coordinating regional dopamine decision signals
The neurotransmitter dopamine is essential for normal reward learning and motivational arousal processes. Indeed these core functions are implicated in the major neurological and psychiatric dopamine disorders such as schizophrenia, substance abuse disorders/addiction and Parkinson's disease. Over the years, we have made significant strides in understanding the dopamine system across multiple levels of description, and I will focus on our recent advances in the computational description, and brain circuit mechanisms that facilitate the dual role of dopamine in learning and performance. I will specifically describe our recent work with imaging the activity of dopamine axons and measurements of dopamine release in mice performing various behavioural tasks. We discovered wave-like spatiotemporal activity of dopamine in the striatal region, and I will argue that this pattern of activation supports a critical computational operation; spatiotemporal credit assignment to regional striatal subexperts. Our findings provide a mechanistic description for vectorizing reward prediction error signals relayed by dopamine.
Rapid Modulation of Cholinergic Interneurons and Dopamine Release by Satellite Astrocytes
Dopamine release in the nucleus accumbens during backward conditioning
COSYNE 2023
Mesolimbic dopamine release conveys causal associations
COSYNE 2023
Continuous theta burst stimulation decreases striatal dopamine release acutely but not chronically: An in vivo and postmortem study
dopamine d4 receptor modulation of electrically stimulated dopamine release in rat brain slices: implication for the treatment of schizophrenia
Altered firing and dopamine release in Substantia Nigra dopaminergic neurons induced by exposure to alpha-synuclein oligomers: From patch-clamp to diamond multielectrode arrays
FENS Forum 2024
Convergent regulation of dopamine release by striatal dopamine transporters and GABA receptors
FENS Forum 2024
Detection of the dopamine release induced by morphine and cocaine treatment using a novel microimaging platform
FENS Forum 2024
New generation of genetically encoded dopamine sensors for imaging brain-wide dopamine release
FENS Forum 2024
The dopamine dialogue: GLP1R agonism suppresses nucleus accumbens dopamine release and food intake
FENS Forum 2024
Exploring the role of axonal voltage-gated sodium channels in the modulation of dopamine release by presynaptic nicotinic receptors
FENS Forum 2024
Glycine receptors regulate striatal cholinergic interneurons and dopamine release
FENS Forum 2024
The influence of lateralized retinal stimulation on dopaminergic neuron activity and striatal dopamine release
FENS Forum 2024
Modulation of cholinergic interneurons and dopamine release by striatal astrocytes
FENS Forum 2024
Real-time imaging of dopamine release and neuronal population dynamics in the motor cortex of awake mice – decoding of reward-related signals and movement parameters
FENS Forum 2024
Regulation of dopamine release by striatal adrenoceptors
FENS Forum 2024
The role of the mu opioid receptors in the ventral tegmental area in the modulation of phasic dopamine release
FENS Forum 2024
Stimuli-evoked noradrenergic activity in the VTA drives phasic dopamine release in the nucleus accumbens – preliminary results
FENS Forum 2024
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