TopicNeuroscience

dorsal raphe

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23ePosters

1Seminar

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Organization of Midbrain Serotonin System

Jing Ren

MRC Laboratory of Molecular Biology, Cambridge

Mar 9, 2021

The serotonin system is the most frequently targeted neural system pharmacologically for treating psychiatric disorders, including depression and anxiety. Serotonin neurons of the dorsal and median raphe nuclei (DR, MR) collectively innervate the entire forebrain and midbrain, modulating diverse physiology and behaviour. By using viral-genetic methods, we found that DR serotonin system contains parallel sub-systems that differ in input and output connectivity, physiological response properties, and behavioural functions. To gain a fundamental understanding of the molecular heterogeneity of DR and MR, we used single-cell RNA - sequencing (scRNA-seq) to generate a comprehensive dataset comprising eleven transcriptomically distinct serotonin neuron clusters. We generated novel intersectional viral-genetic tools to access specific subpopulations. Whole-brain axonal projection mapping revealed that the molecular features of these distinct serotonin groups reflect their anatomical organization and provide tools for future exploration of the full projection map of molecularly defined serotonin groups. The molecular architecture of serotonin system lays the foundation for integrating anatomical, neurochemical, physiological, and behavioural functions.

dorsal raphe

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Organization of Midbrain Serotonin System

Serotonergic activity in the dorsal raphe nucleus through the lens of unsupervised learning

Interactions between the Edinger-Westphal and Dorsal Raphe Nuclei promote parental nesting

Involvement of dorsal raphe nucleus (DRN) astrocytes in valence processing

Depressive and anxious phenotype correlates with functional changes in the ventromedial prefrontal cortex - dorsal raphe nucleus circuit in female mice with alpha-synucleinopathy

Serotonergic neurons in the dorsal raphe regulate visual attention

Age-dependent dynamics in acute and chronic stress-induced FOSB/∆FOSB content in the extended amygdala, hypothalamic paraventricular, habenular, centrally-projecting Edinger-Westphal and dorsal raphe nuclei in male rats

Arginine vasopressin increases the excitatory synaptic drive and firing activity of developing serotonergic neurons in neonatal dorsal raphe nucleus

Characterization of a habenula-driven serotonergic recurrent inhibitory network in dorsal raphe nucleus

Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe–bed nucleus of the stria terminalis pathway

Dorsal raphe modulates the ongoing activity, functional connectivity and sensory responses of zebrafish forebrain circuits

Early life chronic stress alters zebrafish dorsal raphe serotonergic neuron responses to subsequent stressor exposure

Noxious stimulus-responsive neurons in the ventral-ventrolateral periaqueductal gray and dorsal raphe nucleus

The role of MicroRNA-34a on Dorsal Raphe Nuclei neurotransmission in response to specific valence stimuli

Serotonergic and dopaminergic neurons in Dorsal Raphe Nucleus: from physiology to Parkinson’s Disease pathology

Acute and chronic treatment with the nitric oxide synthase inhibitor agmatine stimulates serotonergic neurons in the rat dorsal raphe nucleus

An alternative to treat depression-like behaviors: The effects of S-mecamylamine in the dorsal raphe nucleus

Dorsal raphe nuclei/ventrolateral periaqueductal grey and cerebellar fastigial nucleus interactions modulate danger response during fear learning

Mapping the projections of serotonergic dorsal raphe neurons in zebrafish

Neuronal signature of cognitive flexibility in the prefrontal-dorsal raphe circuit

Noxious stimulus-responsive neurons in the ventral periaqueductal gray and dorsal raphe nucleus

Role of the serotonergic dorsal raphe nucleus in mediating the effects of developmental chronic stress in zebrafish

Serotonin neurons in the dorsal raphe nucleus encode probability rather than value of future rewards

Topographically organized sensory-motor activity of dorsal raphe and its forebrain innervations modulate resting-state and sensory-evoked forebrain activity and animal behavior