In this talk, Dr. Eyo will his present research on microglia, the brain’s resident immune cell. After providing some background to these cells, Dr. Eyo will highlight two aspects of his research. First, some of his previous work elucidating microglial dynamic activity during development as well as mechanisms regulating their demise during simulated developmental ischemia will be discussed. Second, research will be presented clarifying mechanisms underlying the interactions between microglia and neurons with a special focus on seizure disorders. Together, these findings highlight microglia as a critical cell type in brain function in development and brain pathology