early life stress
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The Picower Institute Spring 2023 Symposium "Environmental and Social Determinants of Child Mental Health
Studies show that abuse, neglect or trauma during childhood can lead to lifelong struggles including with mental health. Fortunately research also indicates that solutions and interventions at various stages of life can be developed to help. But even among people who remain resilient or do not experience acute stresses, a lack of opportunity early in life due to poverty or systemic racism can still constrain their ability to realize their full potential. In what ways are health and other outcomes affected by early life difficulty? What can individuals and institutions do to enhance opportunity?" "This daylong event will feature talks by neuroscientists, policy experts, physicians, educators and activists as they discuss how our experiences and biology work together to affect how our minds develop and what can be accomplished in helping people overcome early disadvantages.
Brain and behavioural impacts of early life adversity
Abuse, neglect, and other forms of uncontrollable stress during childhood and early adolescence can lead to adverse outcomes later in life, including especially perturbations in the regulation of mood and emotional states, and specifically anxiety disorders and depression. However, stress experiences vary from one individual to the next, meaning that causal relationships and mechanistic accounts are often difficult to establish in humans. This interdisciplinary talk considers the value of research in experimental animals where stressor experiences can be tightly controlled and detailed investigations of molecular, cellular, and circuit-level mechanisms can be carried out. The talk will focus on the widely used repeated maternal separation procedure in rats where rat offspring are repeatedly separated from maternal care during early postnatal life. This early life stress has remarkably persistent effects on behaviour with a general recognition that maternally-deprived animals are susceptible to depressive-like phenotypes. The validity of this conclusion will be critically appraised with convergent insights from a recent longitudinal study in maternally separated rats involving translational brain imaging, transcriptomics, and behavioural assessment.
The Picower Institute Spring 2021 Symposium: Early Life Stress & Mental Health
Though studies show that abuse, neglect or trauma during childhood can lead to lifelong lifelong struggles including in mental health, research also indicates that solutions and interventions at various stages of life can be developed to help. And while many people manage to remain resilient, a lack of opportunity early in life, including because of poverty and systemic racism, can constrain their ability to realize their full potential. In what ways are health and other outcomes affected? How can systems instead restore opportunity? "The Picower Institute for Learning and Memory's biennial spring symposium, 'Early Life Stress & Mental Health,' will examine these issues. The daylong event will feature talks by neuroscientists, policy experts, physicians, educators and activists as they discuss how our experiences and biology work together to affect how our minds develop and what can be accomplished in helping people overcome early disadvantages.
Behavioral effects of the early life stress, dopaminergic imbalance, and their interplay in male and female prepubertal mice
Early life stress induces epigenetically regulated changes of prefrontal endocannabinoid receptor 1 expression
Early life stress targets the transcriptional signature and functional properties of voltage gated-sodium (Nav) channels in hippocampal NG2+ glia
Effects of early life stress in amygdala microcircuitry and socio-affective behavior: why sex and age matter
Effects of early life stress on the excitability of parvalbumin-expressing GABAergic interneurons in the hippocampus and amygdala
Effects of early life stress on hippocampal NPY-Y2 gene expression changes in male mice via DNA methylation
Elevating anandamide levels restore depression-like phenotype and alterations in micro-RNAs in rats exposed to early life stress
Investigation of NMDA receptor function in a rodent model of early life stress
Stressing but Relaxin’ the brain: how early life stress affects RLN-3 circuitry development and affective behavior
Transient developmental increase in cortical projections to amygdala GABAergic neurons contribute to circuit dysfunction following early life stress
Deciphering the role of neuronal interleukin-1 receptor in early life stress-induced social behavior deficits
FENS Forum 2024
Early life stress and adversities in adulthood: The effects of cumulative stress on memory
FENS Forum 2024
Early life stress & the developmental dynamics of hypothalamic neurogenesis
FENS Forum 2024
Early life stress and living in a complex environment: Effects on social hierarchy and stress coping in mice
FENS Forum 2024
Effects of early life stress on mouse sleep architecture and spindle activity
FENS Forum 2024
Hippocampal neurogenesis changes in a sex and region-specific manner in adult mice subjected to maternal separation as an early life stress
FENS Forum 2024
Impact of early life stress on adult behavior: Insights from mouse model
FENS Forum 2024
Impact of early life stress on the microcircuits of ventral hippocampus and potential targets for phenotype rescue
FENS Forum 2024
Long-term consequences of early life stress on noradrenergic neurons activation in male and female mice
FENS Forum 2024
Metformin administration mitigates early life stress-induced disruptions in hippocampal neurogenesis
FENS Forum 2024
The role of α5-nicotinic receptors on the effects of early life stress in mouse behaviour
FENS Forum 2024
Sex-specific and epigenetically mediated changes of CB1R expression in the medial prefrontal cortex in response to early life stress
FENS Forum 2024
Sympathetic neural-immune interactions involved in early life stress-induced gastrointestinal disorder
FENS Forum 2024
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