TopicNeuroscience

endocannabinoid

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33Total items

29ePosters

4Seminars

Latest

SeminarNeuroscience

Basket cells are key GABAergic inhibitory interneurons that target the somata and proximal dendrites, enabling efficient control of the timing and rate of spiking of their postsynaptic targets. In all cortical circuits, there are two major types of basket cell that exhibit striking developmental, molecular, anatomical, and physiological differences. In this talk, I will discuss recent results that reveal the tightly coupled complementarity of these two key microcircuit regulatory modules, demonstrating a novel form of brain-state-specific segregation of inhibition during spontaneous behavior, with implications for the assessment of dysregulated inhibition in epilepsy. In addition, I will describe recent advances in our understanding of the spatio-temporal dynamics of endocannabinoid signaling in hippocampal circuits and discuss how abnormal amplification of these activity-dependent signaling processes leads to surprising downstream effects in seizures.

SeminarNeuroscienceRecording

Targeting the Endocannabinoid System for Management of Chemotherapy, HIV and Antiretroviral-Induced Neuropathic Pain

Willias Masocha

Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait

Sep 24, 2020

Chemotherapeutic drugs (used for treating cancer), HIV infection and antiretroviral therapy (ART) can independently cause difficult-to-manage painful neuropathy. Paclitaxel, a chemotherapeutic drug, for example is associated with high incidence of peripheral neuropathy, around 71% of the patients of which 27% of these develop neuropathic pain. Use of cannabis or phytocannabinoids has been reported to improve pain measures in patients with neuropathic pain, including painful HIV-associated sensory neuropathy and cancer pain. Phytocannabinoids and endocannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), produce their effects via cannabinoid (CB) receptors, which are present both in the periphery and central nervous system. Endocannabinoids are synthesized in an “on demand” fashion and are degraded by various enzymes such as fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). Various studies, including those from our group, suggest that there are changes in gene and protein expression of endocannabinoid molecules during chemotherapy-induced neuropathic pain (CINP), HIV and antiretroviral-induced neuropathic pain. Analysis of endocannabinoid molecule expression in the brain, spinal cord and paw skin using LC-MS/MS show that there is a specific deficiency of the endocannabinoids 2-AG and/or anandamide in the periphery during CINP. Various drugs including endocannabinoids, cannabidiol, inhibitors of FAAH and MGL, CB receptor agonists, desipramine and coadministered indomethacin plus minocycline have been found to either prevent the development and/or attenuate established CINP, HIV and antiretroviral-induced neuropathic pain in a CB receptor-dependent manner. The results available suggest that targeting the endocannabinoid system for prevention and treatment of CINP, HIV-associated neuropathic pain and antiretroviral-induced neuropathic pain is a plausible therapeutic option.

endocannabinoid

Latest

Endocannabinoid System Dysregulations in Binge Eating Disorder and Obesity

Exploring the endocannabinoid system for intervention innovation in autism

Organization and control of hippocampal circuits in epilepsy

Targeting the Endocannabinoid System for Management of Chemotherapy, HIV and Antiretroviral-Induced Neuropathic Pain

The anti-dyskinetic effects of cannabidiol and HUF-101, a fluorinated cannabidiol derivative, in hemiparkinsonian rats: a possible role of endocannabinoids and TRPV-1 receptors

Comparing the role of the endocannabinoid system in the effects of obesogenic diet on memory in females and males

Dendritic signaling pathways underlying endocannabinoid-mediated inhibitory bouton growth

Distinct activity of endocannabinoid-hydrolyzing enzymes MAGL and FAAH in key regions of peripheral and central nervous system implicated in migraine

Early life stress induces epigenetically regulated changes of prefrontal endocannabinoid receptor 1 expression

Endocannabinoid signalling modulates stress-induced stereotypic behaviors and HPA axis activation

The endocannabinoid system regulates olfactory perception in the anterior piriform cortex

Endocannabinoid-mediated plasticity at cortico-striatal synapses during fast learning

Endocannabinoids modulate Amyloid-β -induced Transglutaminase 2 expression as a marker of Neuroinflammation in mouse models

Impaired cognition and behavior associate with changes in the brain endocannabinoid-dependent synaptic plasticity of adult female mice after binge drinking during adolescence

Inhaled Cannabis Delivery during Pregnancy: Effects on Fetal Brain, Endocannabinoid, and Immune System Development in Rats

Investigating the role of cerebellar endocannabinoids in conditioned fear extinction

Nanoscale adaptations in the striatal endocannabinoid macromolecular complex shape behavioral flexibility

A novel endocannabinoid hydrolase FAAH inhibitor as a potential antidepressant induces gene expression changes in nucleus accumbens in a BALB/c mice acute stress model

Omega-3 impacts on the long-term impaired endocannabinoid system and behavior after binge drinking during adolescence

Omega-3-derived endocannabinoids prevent pro-inflammatory cytokine-induced decreases in human hippocampal neurogenesis and astrogliogenesis, and increase in apoptosis

Regulation of the endocannabinoid system by serotonergic psychedelics: a lipidomic and behavioral study in rodents

Role of the endocannabinoid system in a genetic model of autism based on FMR1 deletion in rats

Acute stress via retrograde endocannabinoid signaling disrupts engram ensemble specificity to generalize threat memory in mice

Behavioural control training promotes antidepressant/anxiolytic-like reversal of chronic stress-induced behavioural deficits: Endocannabinoidergic and prolactinergic mechanisms

Blunted TLR3-induced inflammatory gene expression in the prefrontal cortex of the valproic acid model of autism, an effect unaltered by increasing endocannabinoid tone

Changes in endocannabinoid-dependent synaptic plasticity in CA1 hippocampus of a mouse model of temporal lobe epilepsy

Differential modulation of the endocannabinoid system in binge eating disorder and obesity

Expression of the endocannabinoid system in the visual cortex: Implications for cannabinoid research

A novel form of endocannabinoid-mediated plasticity of tonic GABA inhibition

Omega-3 fatty acids potentiate the endocannabinoid-dependent synaptic plasticity lost after adolescent binge drinking in male mouse dentate gyrus

Potential strategy for the therapeutic regulation of the endocannabinoid system with interfering peptides that modulate SGIP1 binding

Stress-induced potentiation of post-surgical pain and associated alterations in the endocannabinoid system

Targeting the dysfunctional endocannabinoid system in Gulf War Illness