TopicNeuroscience

endogenous opioid system

Content Overview

2Total items

1Seminar

1ePoster

Latest

SeminarNeuroscience

The Kappa Opioid Receptor as Potential Drug Target in TLE

Christoph Schwarzer

Medical University of Innsbruck

Feb 3, 2021

The Kappa Opioid Receptor as Potential Drug Target in TLE Over the last decades, neuropeptides and their receptors received increasing interest as drug targets for multiple purposes. Our interest focuses on the endogenous opioid system and more specifically on dynorphins and the kappa opioid receptor (KOR). Activation of KOR blocks presynaptic Calcium channels and facilitates postsynaptic Potassium release, thereby dampening signal transduction. As KORs are situated on excitatory neurons in the hippocampus, this makes them an interesting target in temporal lobe epilepsy.

ePosterNeuroscience

BINGE-LIKE ALCOHOL EXPOSURE ALTERS TRANSCRIPTIONAL REGULATION OF ENDOGENOUS OPIOID SYSTEM GENES IN PREADOLESCENT RATS

Martina Di Bartolomeo, Mariangela Pucci, Anna Brancato, Valentina Castelli, Gianluca Lavanco, Carla Cannizzaro, Claudio D'Addario

FENS Forum 2026

endogenous opioid system coverage

2 items

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