TopicNeuroscience

endothelial cells

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16Total items

15ePosters

1Seminar

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SeminarNeuroscience

Systemic regulation and measurement of mammalian aging

Tony Wyss-Coray

Stanford University

May 31, 2022

Brain aging leads to cognitive decline and is the main risk factor for sporadic forms of neurodegenerative diseases including Alzheimer’s disease. While brain cell- and tissue-intrinsic factors are likely key determinants of the aging process recent studies document a remarkable susceptibility of the brain to circulatory factors. Thus, blood borne factors from young mice or humans are sufficient to slow aspects of brain aging and improve cognitive function in old mice and, vice versa, factors from old mice are detrimental for young mice and impair cognition. We found evidence that the cerebrovasculature is an important target of circulatory factors and that brain endothelial cells show prominent age-related transcriptional changes in response to plasma. Furthermore, plasma proteins are taken up broadly into the young brain through receptor mediated transport which declines with aging. At the same time, brain derived proteins are detectable in plasma allowing us to measure physiological changes linked to brain aging in plasma. We are exploring the relevance of these findings for neurodegeneration and potential applications towards therapies.

endothelial cells

Latest

Systemic regulation and measurement of mammalian aging

Study of the interaction between microglia and endothelial cells in an Alzheimer's disease mouse model

Characterization of hiPSC-derived endothelial cells role in the formation of cerebral amyloid angiopathy related to Alzheimer’s disease

Exposing microvascular endothelial cells to low energy accelerated protons and its relevance for hadrontherapy applications

Generation of a Blood-Brain Barrier Model using Cryopreserved Human iPSC-derived Brain Microvascular Endothelial Cells, Pericytes, and Astrocytes

Investigating the expression and functional role of Kv7 channels in brain endothelial cells

Metabolic defects in 16p11.2-deficient primary mouse brain endothelial cells

Activation of NOTCH pathway in brain endothelial cells ameliorates vascular abnormalities in Alzheimer's disease mouse models

Cerebral consequences of hypertension and NEMO deletion in brain endothelial cells in mice

Characterization of a new human co-culture model of endothelial cells, pericytes, and brain organoids in a microfluidic device

Cinchonidine, an alkaloid derived from Cinchona, demonstrates neuroprotective properties against ischemic brain injury by enhancing cellular protection in cerebral endothelial cells

Development of an organ-on-chip platform for the co-culture of mouse organotypic brain slices with endothelial cells

Extracellular vesicles: An exploration into the bi-directional crosstalk of endothelial cells and astrocytes at the blood-brain barrier

Novel nanoscale cellular connections between vascular endothelial cells and perivascular glia and between neurons and glia in the developing brain revealed by 3D-EM

NR4A1 is downregulated in human brain microvascular endothelial cells in response to TWEAK stimulation

Nrf2 in brain endothelial cells controls neuroinflammation