TopicNeuroscience

extracellular vesicles

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42Total items

40ePosters

2Seminars

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SeminarNeuroscience

The role of extracellular vesicles in sickness and in health

Vekrellis Konstantinos

Basic Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

Jan 10, 2024

SeminarNeuroscienceRecording

Virus-like intercellular communication in the nervous system

Jason Shepherd

University of Utah

Nov 17, 2020

The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain and mediates various forms of synaptic plasticity. We recently discovered that Arc self-assembles into virus-like capsids that encapsulate RNA. Endogenous Arc protein is released from neurons in extracellular vesicles that mediate the transfer of Arc mRNA into new target cells. Evolutionary analysis indicates that Arc is derived from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to retroviruses such as HIV. These findings suggest that Gag retroelements have been repurposed during evolution to mediate intercellular communication in the nervous system that may underlie cognition and memory.

extracellular vesicles

Latest

The role of extracellular vesicles in sickness and in health

Virus-like intercellular communication in the nervous system

FUNCTIONAL EFFECTS AND RECIPIENT CELLS FOLLOWING PRO-INFLAMMATORY SMALL EXTRACELLULAR VESICLES TRANSFER TO NAÏVE SPINAL CORD EXPLANTS

SEX DIFFERENCES IN THE ACUTE EFFECT OF ASTROCYTE-DERIVED EXTRACELLULAR VESICLES ON THE HYPOTHALAMIC RESPONSE TO HIGH FAT DIET INTAKE

CIRCULATING EXTRACELLULAR VESICLES FROM LIVER INJURY DRIVE NEUROINFLAMMATION IN THE HIPPOCAMPUS

EXTRACELLULAR VESICLES FROM PLASMA OF PATIENTS WITH MINIMAL HEPATIC ENCEPHALOPATHY INDUCE COGNITIVE IMPAIRMENT IN ANIMAL MODEL

HYPERAMMONEMIA INCREASES THE RELEASE OF PATHOLOGICAL EXTRACELLULAR VESICLES FROM MONOCYTES BY IMPAIRING LYSOSOMAL FUNCTION AND AUTOPHAGY THROUGH THE TNFΑ–CAMP–PKA–LC3 PATHWAY

EFFECT OF NEURAL EXTRACELLULAR VESICLES ON THE MODULATION OF CELL SURVIVAL DURING AGING

ASTROCYTE-DERIVED EXTRACELLULAR VESICLES MEDIATE GLYPHOSATE-INDUCED DISRUPTION OF NEURON–GLIA COMMUNICATION

FUNCTIONAL ASPECTS OF EXTRACELLULAR VESICLES IN ALZHEIMER'S DISEASE PATHOLOGY: FROM AMYLOID Β AGGREGATION TO NEURONAL NETWORK DYSFUNCTION

IPSC-DERIVED EXTRACELLULAR VESICLES RESCUE PARKINSON’S DISEASE–ASSOCIATED DEFICITS IN HUMAN AND MOUSE MODELS

BRUTON'S TYROSINE KINASE INHIBITION ENHANCES REMYELINATION VIA MICROGLIAL EXTRACELLULAR VESICLES

PLASMA EXTRACELLULAR VESICLES ACROSS AGEING IN APOE4 MICE: A MULTI-TECHNIQUE CHARACTERIZATION WORKFLOW

SH-SY5Y NEUROBLASTOMA-DERIVED SMALL EXTRACELLULAR VESICLES AT THE BLOOD-BRAIN BARRIER <EM>IN VITRO</EM>: UPTAKE PATTERNS AND PIPELINE FOR INTERACTION ASSESSMENT

UNCOVERING THE ROLE OF EXTRACELLULAR VESICLES IN VPS13A DISEASE: INSIGHTS INTO INTERCELLULAR COMMUNICATION

TARGETED METABOLOMIC PROFILING OF ASTROCYTE LYSATES, CONDITIONED MEDIA AND EXTRACELLULAR VESICLES

COMPARISON OF POLAR METABOLIC PROFILES BETWEEN PLASMA, SERUM, AND PLASMA/SERUM-DERIVED EXTRACELLULAR VESICLES

EXTRACELLULAR VESICLES ISOLATED FROM THE SERUM OF WOMEN DIAGNOSED WITH MAJOR DEPRESSIVE DISORDER ALTER KEY PROCESSES FOR HUMAN MICROGLIA

HUMAN NEURONAL DERIVED EXTRACELLULAR VESICLES IN SUBSTANCE USE DISORDERS

Extracellular vesicles: An exploration into the bi-directional crosstalk of endothelial cells and astrocytes at the blood-brain barrier

Extracellular vesicles from hypothalamic astrocytes modify transcription factors of the leptin signaling pathway in proopiomelanocortin (POMC) neurons

Extracellular vesicles from mesenchymal stem cells alter gut microbiota and improve neuroinflammation and motor impairment in rats with mild liver damage

Extracellular vesicles from MSCs reverse neuroinflammation in cerebellum and restore motor coordination in hyperammonemic rats

Extracellular vesicles from poly I:C-infected airway epithelial cells mediate viral signaling in microglia: Implications for neuroinflammation

Extracellular vesicles and transmission of α-synuclein pathology: From cellular models to diagnostic applications

IL-4-induced microglia-derived small extracellular vesicles exhibit cytoprotective effects against LPS-induced microglial damage through miR-191-5p

Involvement of glioblastoma-derived extracellular vesicles in promoting endothelial cell remodelling: Implications for glioblastoma tumour progression

Loss of neuroprotection in Alzheimer’s disease: Shedding light on BDNF receptor cleavage and its mirroring in extracellular vesicles

Mechanisms of spinocerebellar ataxia type 2 pathogenesis: Insights from small extracellular vesicles

Post-transcriptional regulation of neurodevelopment mediated by extracellular vesicles

Therapeutic effect of extracellular vesicles derived from mesenchymal stem cells in amyotrophic lateral sclerosis

Plasma extracellular vesicles from hyperammonemia rats induce neuroinflammation in the hippocampus and cognitive impairment in control rats

Acute intralesional application of extracellular vesicles improves outcomes in a rat model of traumatic spinal cord injury

Application of extracellular vesicles in a 3D blood-brain barrier spheroid model

Brain region specificity of astrocyte-derived extracellular vesicles: preservation of mitochondrial function in a cellular model of Parkinson’s disease

Characterization of extracellular vesicles released from spinal cord astrocytes of late symptomatic SOD1G93A mouse model of amyotrophic lateral sclerosis

Dysregulation Of Brain-Derived Neurotrophic Factor Receptor In Alzheimer’s Disease Is Mirrored In Extracellular Vesicles

Effect of APOE ε4 allele on redox signature in circulating extracellular vesicles from cognitively impaired with no dementia participants converted to Alzheimer’s disease

Extracellular vesicles from human iPSC-derived neural stem cells alleviate microglial response and cognitive impairments in a chronic neuroinflammation model

Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats by reducing NF-κB activation via TGFβ receptor activation

Extracellular vesicles underlie cell-type-specific crosstalk during human cortical development

Functional recovery caused by human adipose tissue mesenchymal stem cell-derived extracellular vesicles administered 24h after stroke in normotensive rats and some differences to hypertensive rats