TopicNeuroscience

extracellular vesicles

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31Total items

29ePosters

2Seminars

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SeminarNeuroscience

The role of extracellular vesicles in sickness and in health

Vekrellis Konstantinos

Basic Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

Jan 10, 2024

SeminarNeuroscienceRecording

Virus-like intercellular communication in the nervous system

Jason Shepherd

University of Utah

Nov 17, 2020

The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain and mediates various forms of synaptic plasticity. We recently discovered that Arc self-assembles into virus-like capsids that encapsulate RNA. Endogenous Arc protein is released from neurons in extracellular vesicles that mediate the transfer of Arc mRNA into new target cells. Evolutionary analysis indicates that Arc is derived from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to retroviruses such as HIV. These findings suggest that Gag retroelements have been repurposed during evolution to mediate intercellular communication in the nervous system that may underlie cognition and memory.

extracellular vesicles

Latest

The role of extracellular vesicles in sickness and in health

Virus-like intercellular communication in the nervous system

Acute intralesional application of extracellular vesicles improves outcomes in a rat model of traumatic spinal cord injury

Application of extracellular vesicles in a 3D blood-brain barrier spheroid model

Brain region specificity of astrocyte-derived extracellular vesicles: preservation of mitochondrial function in a cellular model of Parkinson’s disease

Characterization of extracellular vesicles released from spinal cord astrocytes of late symptomatic SOD1G93A mouse model of amyotrophic lateral sclerosis

Dysregulation Of Brain-Derived Neurotrophic Factor Receptor In Alzheimer’s Disease Is Mirrored In Extracellular Vesicles

Effect of APOE ε4 allele on redox signature in circulating extracellular vesicles from cognitively impaired with no dementia participants converted to Alzheimer’s disease

Extracellular vesicles from human iPSC-derived neural stem cells alleviate microglial response and cognitive impairments in a chronic neuroinflammation model

Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats by reducing NF-κB activation via TGFβ receptor activation

Extracellular vesicles underlie cell-type-specific crosstalk during human cortical development

Functional recovery caused by human adipose tissue mesenchymal stem cell-derived extracellular vesicles administered 24h after stroke in normotensive rats and some differences to hypertensive rats

A miRNA fingerprint in Plasma-derived extracellular vesicles of hSOD1G93A transgenic swine

Role of neuron-derived extracellular vesicles in synaptic plasticity

Small Extracellular Vesicles from Peripheral Blood of Aged Mice Pass the Blood-Brain Barrier and Induce Glial Cell Activation

Characterizing nerve-derived extracellular vesicles: Potentials and pitfalls

Deciphering the role of specific membrane transporters in extracellular vesicles

Endogenous alpha-Synuclein is essential for the transfer of pathology by exosome-enriched extracellular vesicles, following inoculation with preformed fibrils in vivo

Extracellular vesicles: An exploration into the bi-directional crosstalk of endothelial cells and astrocytes at the blood-brain barrier

Extracellular vesicles from hypothalamic astrocytes modify transcription factors of the leptin signaling pathway in proopiomelanocortin (POMC) neurons

Extracellular vesicles from mesenchymal stem cells alter gut microbiota and improve neuroinflammation and motor impairment in rats with mild liver damage

Extracellular vesicles from MSCs reverse neuroinflammation in cerebellum and restore motor coordination in hyperammonemic rats

Extracellular vesicles from poly I:C-infected airway epithelial cells mediate viral signaling in microglia: Implications for neuroinflammation

Extracellular vesicles and transmission of α-synuclein pathology: From cellular models to diagnostic applications

IL-4-induced microglia-derived small extracellular vesicles exhibit cytoprotective effects against LPS-induced microglial damage through miR-191-5p

Involvement of glioblastoma-derived extracellular vesicles in promoting endothelial cell remodelling: Implications for glioblastoma tumour progression

Loss of neuroprotection in Alzheimer’s disease: Shedding light on BDNF receptor cleavage and its mirroring in extracellular vesicles

Mechanisms of spinocerebellar ataxia type 2 pathogenesis: Insights from small extracellular vesicles

Plasma extracellular vesicles from hyperammonemia rats induce neuroinflammation in the hippocampus and cognitive impairment in control rats

Post-transcriptional regulation of neurodevelopment mediated by extracellular vesicles

Therapeutic effect of extracellular vesicles derived from mesenchymal stem cells in amyotrophic lateral sclerosis