TopicNeuroscience

focused ultrasound

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16Total items

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1Seminar

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SeminarNeuroscience

MBI Webinar on preclinical research into brain tumours and neurodegenerative disorders

Ekaterina (Caty) Salimova and Ms Sanjeevini Babu Reddiar

Apr 13, 2022

WEBINAR 1 Breaking the barrier: Using focused ultrasound for the development of targeted therapies for brain tumours presented by Dr Ekaterina (Caty) Salimova, Monash Biomedical Imaging Glioblastoma multiforme (GBM) - brain cancer - is aggressive and difficult to treat as systemic therapies are hindered by the blood-brain barrier (BBB). Focused ultrasound (FUS) - a non-invasive technique that can induce targeted temporary disruption of the BBB – is a promising tool to improve GBM treatments. In this webinar, Dr Ekaterina Salimova will discuss the MRI-guided FUS modality at MBI and her research to develop novel targeted therapies for brain tumours. Dr Ekaterina (Caty) Salimova is a Research Fellow in the Preclinical Team at Monash Biomedical Imaging. Her research interests include imaging cardiovascular disease and MRI-guided focused ultrasound for investigating new therapeutic targets in neuro-oncology. - WEBINAR 2 Disposition of the Kv1.3 inhibitory peptide HsTX1[R14A], a novel attenuator of neuroinflammation presented by Sanjeevini Babu Reddiar, Monash Institute of Pharmaceutical Sciences The voltage-gated potassium channel (Kv1.3) in microglia regulates membrane potential and pro-inflammatory functions, and non-selective blockade of Kv1.3 has shown anti-inflammatory and disease improvement in animal models of Alzheimer’s and Parkinson’s diseases. Therefore, specific inhibitors of pro-inflammatory microglial processes with CNS bioavailability are urgently needed, as disease-modifying treatments for neurodegenerative disorders are lacking. In this webinar, PhD candidate Ms Sanju Reddiar will discuss the synthesis and biodistribution of a Kv1.3-inhibitory peptide using a [64Cu]Cu-DOTA labelled conjugate. Sanjeevini Babu Reddiar is a PhD student at the Monash Institute of Pharmaceutical Sciences. She is working on a project identifying the factors governing the brain disposition and blood-brain barrier permeability of a Kv1.3-blocking peptide.

focused ultrasound

Latest

MBI Webinar on preclinical research into brain tumours and neurodegenerative disorders

FOCUSED ULTRASOUND RESCUES MEMORY DEFICITS IN THE 5XFAD MOUSE MODEL OF ALZHEIMER’S DISEASE WITHOUT LOWERING AMYLOID-Β

ISOFLURANE DEPTH SHAPES TRANSCRANIAL FOCUSED ULTRASOUND INDUCED NEUROMODULATION IN THE PREFRONTAL CORTEX IN MICE

RESTORING SYNAPTIC PLASTICITY IN THE DEMYELINATED BRAIN: THE THERAPEUTIC EFFICACY OF FOCUSED ULTRASOUND IN THE HIPPOCAMPUS

BRIEF TRANSCRANIAL FOCUSED ULTRASOUND STIMULATION CAUSES LASTING MODIFICATIONS TO THE SYNAPTIC CIRCUITRY OF THE HIPPOCAMPUS

A MINIATURIZED TRANSCRANIAL FOCUSED ULTRASOUND DEVICE FOR NEUROMODULATION RESEARCH

A COMPUTATIONAL APPROACH TO MODELING FOCUSED ULTRASOUND EFFECTS ON PERIPHERAL NERVES

PIEZOELECTRIC JANUS MICROPARTICLES ENABLE WIRELESS NEURAL STIMULATION VIA LOW-INTENSITY FOCUSED ULTRASOUND

A MULTISCALE COMPUTATIONAL FRAMEWORK FOR MICROBUBBLE CAVITATION UNDER SKULL-DISTORTED TRANSCRANIAL FOCUSED ULTRASOUND

INVESTIGATING THE ROLE OF PERICYTES IN ALZHEIMER’S DISEASE DRUG DELIVERY USING IPSC-DERIVED BBB MODELS AND FOCUSED ULTRASOUND

TRANSCRANIAL FOCUSED ULTRASOUND FOR SEIZURE MODULATION: PARAMETER MAPPING IN THE INTRAHIPPOCAMPAL KAINIC ACID MOUSE MODEL USING FIBER PHOTOMETRY

Characterization of transcranial focused ultrasound stimulation using calcium imaging with fiber photometry in mice

Enhancement of cerebrospinal fluid movement by transcranial focused ultrasound stimulation

Lateralization of motor responses following focused ultrasound neuromodulation of the motor cortex and thalamus in awake mice

Single administration of focused ultrasound-mediated blood-brain barrier opening is antidepressant with Claudin-5 remodeling

A stereotactic atlas based 3D model of MR guided focused ultrasound thalamotomy targets