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Orbitofrontal cortex and the integrative approach to functional neuroanatomy
The project of functional neuroanatomy typically considers single brain areas as the core functional unit of the brain. Functional neuroanatomists typically use specialized tasks that are designed to isolate hypothesized functions from other cognitive processes. Our lab takes a broader view; specifically, we consider brain regions as parts of larger circuits and we take cognitive processes as part of more complex behavioral repertoires. In my talk, I will discuss the ramifications of this perspective for thinking about the role of the orbitofrontal cortex. I will discuss results of recent experiments from my lab that tackle the question of OFC function within the context of larger brain networks and in freely moving foraging tasks. I will argue that this perspective challenges conventional accounts of the role of OFC and invites new ones. I will conclude by speculating on implications for the practice of functional neuroanatomy.
Effort-based decision-making versus spontaneous foraging tasks reveal divergence in antidepressant effects on motivation in mice
FENS Forum 2024
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