functional insights
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Cell type-specific gene regulatory mechanisms associated with addiction-related behaviors in rats
Understanding the fundamental gene regulatory mechanisms underlying addiction and related behaviors could facilitate more effective treatments. We discuss our work using multi-omics methods to provide mechanistic and functional insights into how addiction perturbs gene regulatory programs in the rat brain, with single-cell resolution.
Autism spectrum disorder: from gene discovery to functional insights
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting up to 1% of the population. Over the past few years, large-scale genomic studies have identified hundreds of genetic loci associated with liability to ASD. It is now time to translate these genetic discoveries into functional studies that can help us understand convergences and divergences across risk genes, and build pre-clinical cell and animal models. In this seminar, I will discuss some of the most recent findings on the genetic risk architecture of ASD. I will then expand on our work on biomarkers discovery and neurodevelopmental analyses in two rare genetic conditions associated with ASD: ADNP and DDX3X syndrome.
STRUCTURAL AND FUNCTIONAL INSIGHTS INTO CAMKIIΓ AND DISEASE-LINKED VARIANTS
FENS Forum 2026
INTEGRATION OF HUMAN IPSC- DERIVED MICROGLIA IN ADHERENT CORTICAL ORGANOIDS: STRUCTURAL AND FUNCTIONAL INSIGHTS
FENS Forum 2026
FUNCTIONAL INSIGHTS INTO HETEROZYGOUS <EM>ITPR1</EM> VARIANTS ASSOCIATED WITH ATAXIA AND MIOSIS
FENS Forum 2026
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