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Adaptive deep brain stimulation to treat gait disorders in Parkinson's disease; Personalized chronic adaptive deep brain stimulation outperforms conventional stimulation in Parkinson's disease
On Friday, August 31st we will host Stephanie Cernera & Doris Wang! Stephanie Cernera, PhD, is a postdoctoral research fellow in the Starr lab at University of California San Francisco. She will tell us about “Personalized chronic adaptive deep brain stimulation outperforms conventional stimulation in Parkinson’s Disease”. Doris Wang, MD, PhD, is a neurosurgeon and assistant professor at the University of California San Francisco. Apart from her scientific presentation about “Adaptive Deep Brain Stimulation to Treat Gait Disorders in Parkinson’s Disease”, she will give us a glimpse at the “Person behind the science”. The talks will be followed by a shared discussion. You can register via talks.stimulatingbrains.org to receive the (free) Zoom link!
Computational models of spinal locomotor circuitry
To effectively move in complex and changing environments, animals must control locomotor speed and gait, while precisely coordinating and adapting limb movements to the terrain. The underlying neuronal control is facilitated by circuits in the spinal cord, which integrate supraspinal commands and afferent feedback signals to produce coordinated rhythmic muscle activations necessary for stable locomotion. I will present a series of computational models investigating dynamics of central neuronal interactions as well as a neuromechanical model that integrates neuronal circuits with a model of the musculoskeletal system. These models closely reproduce speed-dependent gait expression and experimentally observed changes following manipulation of multiple classes of genetically-identified neuronal populations. I will discuss the utility of these models in providing experimentally testable predictions for future studies.
Monitoring gait outcomes in rehabilitation with human pose estimation and wearable sensors
Functional gait disorders: a sign-based approach
How to assess and manage spastic gait in rare diseases?
Acquisition of a complex locomotor task: activity of cerebellar molecular layer interneurons and gait dynamics
Characterization of impaired motor movements in a mouse model of freezing of gait
Closed-loop neuromodulation of spinal circuits for the treatment of gait deficits in animal models of Parkinson’s disease
Effect of static transcranial magnetic stimulation over left-DLPFC on fatigue produced by human gait
Effects of directional subthalamic deep brain stimulation on gait and balance in Parkinson Disease patients
Electrical Stimulation of Spinal Circuits for Gait Recovery in Parkinson’s Disease
The emergence of fixed points in interlimb coordination underlies the learning of stable gaits in mice
A graph-based model of the effect of deep brain stimulation on cortico-subcortical networks in the context of freezing of gait in Parkinson’s disease
Imaging neural activity dynamics during gait switching in larval zebrafish
Inhibition and gait initiation in healthy subjects : an EEG study
Intensive sensorimotor rehabilitation restores gait disfunction and microstructure caused by experimental cerebral palsy in rats
A paradigm to behaviourally decouple the top-down and feedback influences on locomotor gait
Recovery of Turning Gaits in Parkinsonian Mice by Targeted Stimulation of Brainstem Neurons
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