genetic interactions
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Zebrafish models help untangle genetic interactions in motor neuron degeneration
Due to high homology to the human genome and rapid development, zebrafish have been successfully used to model diseases of the neuromuscular system. In this seminar, I will present current advances in modeling genetic causes of Amyotrophic Lateral Sclerosis (ALS), the most common motor neuron degeneration and show how epistatic interaction studies in zebrafish have helped elucidate synergistic effects of major ALS genes and their cellular targets.
Exploring genetic interactions of the mutant Huntingtin protein using Drosophila and mouse models of Huntington's Disease
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