TopicNeuroscience

glioblastoma

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43Total items

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3Seminars

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SeminarNeuroscience

Astrocytes release glutamate by regulated exocytosis in health and disease

Vladimir Parpura

Distinguished Professor Zhejiang Chinese Medical University and Director of the International Translational Neuroscience Research Institute, Hangzhou, P.R. China

Jun 5, 2025

Astrocytes release glutamate by regulated exocytosis in health and disease Vladimir Parpura, International Translational Neuroscience Research Institute, Zhejiang Chinese Medical University, Hangzhou, P.R. China Parpura will present you with the evidence that astrocytes, a subtype of glial cells in the brain, can exocytotically release the neurotransmitter glutamate and how this release is regulated. Spatiotemporal characteristic of vesicular fusion that underlie glutamate release in astrocytes will be discussed. He will also present data on a translational project in which this release pathway can be targeted for the treatment of glioblastoma, the deadliest brain cancer.

SeminarNeuroscience

MBI Webinar on preclinical research into brain tumours and neurodegenerative disorders

Ekaterina (Caty) Salimova and Ms Sanjeevini Babu Reddiar

Apr 13, 2022

WEBINAR 1 Breaking the barrier: Using focused ultrasound for the development of targeted therapies for brain tumours presented by Dr Ekaterina (Caty) Salimova, Monash Biomedical Imaging Glioblastoma multiforme (GBM) - brain cancer - is aggressive and difficult to treat as systemic therapies are hindered by the blood-brain barrier (BBB). Focused ultrasound (FUS) - a non-invasive technique that can induce targeted temporary disruption of the BBB – is a promising tool to improve GBM treatments. In this webinar, Dr Ekaterina Salimova will discuss the MRI-guided FUS modality at MBI and her research to develop novel targeted therapies for brain tumours. Dr Ekaterina (Caty) Salimova is a Research Fellow in the Preclinical Team at Monash Biomedical Imaging. Her research interests include imaging cardiovascular disease and MRI-guided focused ultrasound for investigating new therapeutic targets in neuro-oncology. - WEBINAR 2 Disposition of the Kv1.3 inhibitory peptide HsTX1[R14A], a novel attenuator of neuroinflammation presented by Sanjeevini Babu Reddiar, Monash Institute of Pharmaceutical Sciences The voltage-gated potassium channel (Kv1.3) in microglia regulates membrane potential and pro-inflammatory functions, and non-selective blockade of Kv1.3 has shown anti-inflammatory and disease improvement in animal models of Alzheimer’s and Parkinson’s diseases. Therefore, specific inhibitors of pro-inflammatory microglial processes with CNS bioavailability are urgently needed, as disease-modifying treatments for neurodegenerative disorders are lacking. In this webinar, PhD candidate Ms Sanju Reddiar will discuss the synthesis and biodistribution of a Kv1.3-inhibitory peptide using a [64Cu]Cu-DOTA labelled conjugate. Sanjeevini Babu Reddiar is a PhD student at the Monash Institute of Pharmaceutical Sciences. She is working on a project identifying the factors governing the brain disposition and blood-brain barrier permeability of a Kv1.3-blocking peptide.

SeminarNeuroscienceRecording

Sparks, flames, and inferno: epileptogenesis in the glioblastoma microenvironment

Jeff Noebels

Baylor College of Medicine

Oct 7, 2020

Glioblastoma cells trigger pharmacoresistant seizures that may promote tumor growth and diminish the quality of remaining life. To define the relationship between growth of glial tumors and their neuronal microenvironment, and to identify genomic biomarkers and mechanisms that may point to better prognosis and treatment of drug resistant epilepsy in brain cancer, we are analyzing a new generation of genetically defined CRISPR/in utero electroporation inborn glioblastoma (GBM) tumor models engineered in mice. The molecular pathophysiology of glioblastoma cells and surrounding neurons and untransformed astrocytes are compared at serial stages of tumor development. Initial studies reveal that epileptiform EEG spiking is a very early and reliable preclinical signature of GBM expansion in these mice, followed by rapidly progressive seizures and death within weeks. FACS-sorted transcriptomic analysis of cortical astrocytes reveals the expansion of a subgroup enriched in pro-synaptogenic genes that may drive hyperexcitability, a novel mechanism of epileptogenesis. Using a prototypical GBM IUE model, we systematically define and correlate the earliest appearance of cortical hyperexcitability with progressive cortical tumor cell invasion, including spontaneous episodes of spreading cortical depolarization, innate inflammation, and xCT upregulation in the peritumoral microenvironment. Blocking this glutamate exporter reduces seizure load. We show that the host genome contributes to seizure risk by generating tumors in a monogenic deletion strain (MapT/tau -/-) that raises cortical seizure threshold. We also show that the tumor variant profile determines epilepsy risk. Our genetic dissection approach sets the stage to broadly explore the developmental biology of personalized tumor/host interactions in mice engineered with novel human tumor mutations in specified glial cell lineages.

glioblastoma

Latest

Astrocytes release glutamate by regulated exocytosis in health and disease

MBI Webinar on preclinical research into brain tumours and neurodegenerative disorders

Sparks, flames, and inferno: epileptogenesis in the glioblastoma microenvironment

Acquired inheritable factors for brain fitness in the progression of glioblastoma

Alteration of the mitochondrial activity and lipidic metabolism caused by the selective stimulation of M2 muscarinic receptors in human glioblastoma cells

Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas

Changes in adenosine A2A receptor availability in glioblastoma

The combined efficiency of Thymoquinone and Curcumin on Glioblastoma cells

CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation

Co-Targeting Tumor Microenvironment-Instigated Adaptation To Hypoxia Renders Glioblastoma More Susceptible To Oncolytic Virus Immunotherapy

Delineating the immediate molecular consequences of the glioblastoma-associated H3.3K27M mutation

Evaluation of the effect of KetoVOLVE and medium-chain triglyceride based ketogenic diet on PPARs gene modulation in glioblastoma tumor development

Extracellular proteins – a source of amino acids for human glioblastoma cells

Glioblastoma Multiforme: study of the synergic effect of medicinal mushrooms and new platinum compound in U251 human glioblastoma cell line

Glucocorticoid drug withdrawal exacerbates glioblastoma multiforme malignancy

Immunomodulatory effects of pulsed electric field stimulation in a murine glioblastoma model

Integrated computational and experimental single cell analyses reveals MPST as a critical metabolic vulnerability for motile glioblastoma cells

Manipulating Neural Stem Cells to create a transgenic independent model for glioblastoma

Mechanistic insights into VAMP7-dependent unconventional secretion in neuron-glioblastoma cell communication

The metabolism of essential amino acids by human glioblastomas

Neuroinflamm-aging of the microenvironment during glioblastoma progression

Neuronal Na+/Ca2+ Exchanger 2 (NCX2) as a tumor suppressor protein in Glioblastoma Progression and Malignity

Neuron-glioma interactions in white matter invasion in a preclinical model of glioblastoma

NR5A2 as a potential drug target in Glioblastomas

Sialic acid metabolism orchestrates transcellular connectivity and signaling in glioblastoma

STAT3-mediated astrocytic reactivity in glioblastoma multiforme

In vitro targeting-treatment potential of chlorotoxin peptide-functionalized nanoparticles in neuroblastoma and glioblastoma cells

In vivo intratumoral calcium heterogeneity in Glioblastoma Multiforme correlates with migrational patterns

Assessment of metabolome in the tumor microenvironment by cerebral open flow microperfusion (cOFM) in a human glioblastoma xenograft animal model

Characterization of exosomes isolated from glioblastoma (U-87) cells and their use as prophylactic in Alzheimer's disease

Detrimental effects of high-density STAT3-mediated astrocytic corralling in glioblastoma multiforme

DIAPH3 as a survival prognostic factor in glioblastoma patients

Effect of polybrene on different glioblastoma subtypes

Elucidating the role of VAMP7-dependent late endosomal autophagic secretion in glioblastoma progression

Ethanol extract of Vanilla planifolia stem reduced PAK6 expression and induced cell death in glioblastoma cells

Interaction between M2 muscarinic receptors and β-1 arrestin in glioblastoma cell lines: Effects mediated by orthosteric and dualsteric agonists

Investigating the role of hyperphosphorylated tau in both neurodegenerative disease and glioblastoma using adult human organotypic slice cultures

Involvement of glioblastoma-derived extracellular vesicles in promoting endothelial cell remodelling: Implications for glioblastoma tumour progression

LRIG1 regulates the balance between proliferation and quiescence in glioblastoma stem cells

Machine learning identifies potential anti-glioblastoma small molecules

Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy

The morphology of glioblastoma stem cells impacts tumour progression

Parvalbumin interneurons protect peritumoral tissue from glioblastoma growth