high fat diet

Impact of High Fat Diet on Central Cardiac Circuits: When The Wanderer is Lost

Cardiac vagal motor drive originates in the brainstem's cardiac vagal motor neurons (CVNs). Despite well-established cardioinhibitory functions in health, our understanding of CVNs in disease is limited. There is a clear connection of cardiovascular regulation with metabolic and energy expenditure systems. Using high fat diet as a model, this talk will explore how metabolic dysfunction impacts the regulation of cardiac tissue through robust inhibition of CVNs. Specifically, it will present an often overlooked modality of inhibition, tonic gamma-aminobuytric acid (GABA) A-type neurotransmission using an array of techniques from single cell patch clamp electrophysiology to transgenic in vivo whole animal physiology. It also will highlight a unique interaction with the delta isoform of protein kinase C to facilitate GABA A-type receptor expression.

SEX DIFFERENCES IN THE ACUTE EFFECT OF ASTROCYTE-DERIVED EXTRACELLULAR VESICLES ON THE HYPOTHALAMIC RESPONSE TO HIGH FAT DIET INTAKE

FENS Forum 2026

Chronic exposure to high fat diet affects the dopamine modulation in nucleus accumbens of adolescent male rats: Implications in hedonic food intake

High fat diet feeding disrupts nucleus accumbens core regulated motivational control over food-seeking behaviour

Locomotor and explorative behaviour of juvenile male mouse offspring were altered by maternal high fat diet during the preimplantation

Lifelong exposure to high fat diet leads to depressive-like phenotype associated with increased central amyloid oligomer formation

FENS Forum 2024