high fat diet

Impact of High Fat Diet on Central Cardiac Circuits: When The Wanderer is Lost

Cardiac vagal motor drive originates in the brainstem's cardiac vagal motor neurons (CVNs). Despite well-established cardioinhibitory functions in health, our understanding of CVNs in disease is limited. There is a clear connection of cardiovascular regulation with metabolic and energy expenditure systems. Using high fat diet as a model, this talk will explore how metabolic dysfunction impacts the regulation of cardiac tissue through robust inhibition of CVNs. Specifically, it will present an often overlooked modality of inhibition, tonic gamma-aminobuytric acid (GABA) A-type neurotransmission using an array of techniques from single cell patch clamp electrophysiology to transgenic in vivo whole animal physiology. It also will highlight a unique interaction with the delta isoform of protein kinase C to facilitate GABA A-type receptor expression.

Chronic exposure to high fat diet affects the dopamine modulation in nucleus accumbens of adolescent male rats: Implications in hedonic food intake

High fat diet feeding disrupts nucleus accumbens core regulated motivational control over food-seeking behaviour

Locomotor and explorative behaviour of juvenile male mouse offspring were altered by maternal high fat diet during the preimplantation

Lifelong exposure to high fat diet leads to depressive-like phenotype associated with increased central amyloid oligomer formation

FENS Forum 2024