hippocampal theta

Manipulating single-unit theta phase-locking with PhaSER: An open-source tool for real-time phase estimation and manipulation

Zoe has developed an open-source tool PhaSER, which allows her to perform real-time oscillatory phase estimation and apply optogenetic manipulations at precise phases of hippocampal theta during high-density electrophysiological recordings in head-fixed mice while they navigate a virtual environment. The precise timing of single-unit spiking relative to network-wide oscillations (i.e., phase locking) has long been thought to maintain excitatory-inhibitory homeostasis and coordinate cognitive processes, but due to intense experimental demands, the causal influence of this phenomenon has never been determined. Thus, we developed PhaSER (Phase-locked Stimulation to Endogenous Rhythms), a tool which allows the user to explore the temporal relationship between single-unit spiking and ongoing oscillatory activity.

HIPPOCAMPAL THETA-GAMMA PHASE-AMPLITUDE COUPLING CODES FOR THE DISTANCE TO HIDDEN GOAL LOCATIONS IN HUMAN INTRACRANIAL EEG

FENS Forum 2026

ACUTE TRAUMATIC STRESS INDUCES ABNORMAL HIPPOCAMPAL THETA OSCILLATION AND PREDICTS MALADAPTIVE PLASTICITY

FENS Forum 2026

Noradrenergic mediation of hippocampal theta rhythm induced by vagal nerve stimulation

Sampling-based representation of uncertainty during hippocampal theta sequences

COSYNE 2023

Specific ablation of hippocampal theta activity during locomotion impairs learning

FENS Forum 2024

Changes in frequency and amplitude of hippocampal theta modulate firing across neurons with respect to behavioural context

FENS Forum 2024

Hippocampal theta sweeps are a data-efficient algorithm for cognitive map formation

COSYNE 2025