Intracellular Ca2

Firing Rate Homeostasis in Neural Circuits: From basic principles to malfunctions

Maintaining average activity level within a set-point range constitutes a fundamental property of central neural circuits. Accumulated evidence suggests that firing rate distributions and their means represent physiological variables regulated by homeostatic systems during sleep-wake cycle in central neural circuits. While intracellular Ca2+ has long been hypothesized as a feedback control signal, the source of Ca2+ and the molecular machinery enabling network-wide homeostatic responses remain largely unknown. I will present our hypothesis and framework on identifying homeostatic regulators in neural circuits. Next, I will show our new results on the role of mitochondria in the regulation of activity set-points and feedback responses. Finally, I will provide an evidence on state-dependent dysregulation of activity set-points at the presymptomatic disease stage in familial Alzheimer’s models.

Role of intracellular Ca2+ stores in synaptic tag and capture in mouse hippocampal slices

Intracellular Ca2+ signal in hippocampal astrocytes from WT and A7KO mice along aging

FENS Forum 2024

Lavandula angustifolia or astrocytes alleviate nicotine plus high glucose-induced intracellular Ca2+ elevation in neurons and microglia

FENS Forum 2024