kinematics

Mouse Motor Cortex Circuits and Roles in Oromanual Behavior

I’m interested in structure-function relationships in neural circuits and behavior, with a focus on motor and somatosensory areas of the mouse’s cortex involved in controlling forelimb movements. In one line of investigation, we take a bottom-up, cellularly oriented approach and use optogenetics, electrophysiology, and related slice-based methods to dissect cell-type-specific circuits of corticospinal and other neurons in forelimb motor cortex. In another, we take a top-down ethologically oriented approach and analyze the kinematics and cortical correlates of “oromanual” dexterity as mice handle food. I'll discuss recent progress on both fronts.

Cortex-dependent corrections as the mouse tongue reaches for and misses targets

Brendan Ito (Cornell University, USA) and Teja Bollu (Salk Institute, USA) share unique insights into rapid online motor corrections during mouse licking, analogous to primate goal-oriented reaching. Techniques covered include large-scale single unit recording during behaviour with optogenetics, and a deep-learning-based neural network to resolve 3D tongue kinematics during licking.

A Single-Layer Neuromorphic Encoder Maps EMG Signals into Wrist Kinematics

Bernstein Conference 2024

Movement Direction and Joint Kinematics Define Trajectory Variability Patterns

Purkinje cell microzones mediate distinct kinematics of a single movement

Simultaneous yet separable population encoding of arm movement direction and kinematics in motor cortex

Spatio-temporal dependency of striatal dopamine in the control of movement kinematics in rats

Kinematics analysis of recovered forelimb function by forced limb use after hemorrhagic stroke in rats

FENS Forum 2024

Mice learn to adapt to visuomotor perturbations by rapidly adapting limb kinematics

FENS Forum 2024

Tri-dimensional kinematics of locomotor steering strategies in freely moving mice

FENS Forum 2024