TopicNeuroscience

lateral habenula

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23Total items

22ePosters

1Seminar

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SeminarNeuroscience

Astroglial modulation of the antidepressant action of deep brain and bright light stimulation

Nasser Haddjeri

Stem Cell And Brain Research Institute, INSERM 1208, Bron, France

Apr 8, 2022

Even if major depression is now the most common of psychiatric disorders, successful antidepressant treatments are still difficult to achieve. Therefore, a better understanding of the mechanisms of action of current antidepressant treatments is needed to ultimately identify new targets and enhance beneficial effects. Given the intimate relationships between astrocytes and neurons at synapses and the ability of astrocytes to "sense" neuronal communication and release gliotransmitters, an attractive hypothesis is emerging stating that the effects of antidepressants on brain function could be, at least in part, modulated by direct influences of astrocytes on neuronal networks. We will present two preclinical studies revealing a permissive role of glia in the antidepressant response: i) Control of the antidepressant-like effects of rat prefrontal cortex Deep Brain Stimulation (DBS) by astroglia, ii) Modulation of antidepressant efficacy of Bright Light Stimulation (BLS) by lateral habenula astroglia. Therefore, it is proposed that an unaltered neuronal-glial system constitutes a major prerequisite to optimize antidepressant efficacy of DBS or BLS. Collectively, these results pave also the way to the development of safer and more effective antidepressant strategies.

lateral habenula

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Astroglial modulation of the antidepressant action of deep brain and bright light stimulation

A NOVEL BRAINSTEM REWARD CENTER INHIBITS THE LATERAL HABENULA

LITHIUM PROMOTES SUSTAINED ACTIVE COPING BEHAVIOR BY ATTENUATING NEURAL ACTIVITY OF THE LATERAL HABENULA

UNCONTROLLABLE STRESS IMPAIRS THE ACQUISITION OF CONDITIONED INHIBITION: IMPLICATIONS FOR THE INVOLVEMENT OF THE LATERAL HABENULA

LIGHTING UP THE LATERAL HABENULA: SEX-SPECIFIC 5-HT2C PATHWAYS IN STRESS AND DEPRESSION

ELECTROPHYSIOLOGICAL ANALYSIS OF THE LATERAL HABENULA UNDER ACUTE STRESS

UNVEILING AN ENDOGENOUS SOURCE OF CHOLINERGIC TRANSMISSION IN THE LATERAL HABENULA

SPIKING DYNAMICS IN LATERAL HABENULA AND RAPHE NUCLEI REVEALED BY HIGH-DENSITY RECORDINGS

EFFECTS OF CHRONIC NEWBORN DISTRESS CALLS ON LATERAL HABENULA FUNCTION AND ADULT-NEWBORN INTERACTIONS IN VIRGIN FEMALE MICE

MECHANISMS GOVERNING THE DEVELOPMENT OF SYNAPTIC TRANSMISSION IN THE LATERAL HABENULA

LATERAL HABENULA AS A NOVEL MECHANISM REGULATING SYSTEMIC IMMUNE RESPONSES

Nigroincertal activation engages lateral habenula and periaqueductal gray

Integrating information and reward into subjective value: humans, monkeys, and the lateral habenula

Plasticity in the lateral habenula after adult-newborn interactions

Integrating information and reward into subjective value: humans, monkeys, and the lateral habenula

Acetylcholine and Lateral Habenula partnership in shaping punishment anticipation

Experience-dependent plasticity of burst activity in lateral habenula neurons

Including the lateral habenula in the stress-related functional network

Responses of lateral habenula neurons to an aversive stimulus across alternating brain states of urethane anaesthetised rat

Role of a lateral hypothalamus-lateral habenula pathway in cocaine-induced psychomotor responses

Ventral Pallidum activation differentially modulates the Mediodorsal Thalamus and the Lateral Habenula of rats

Dynamics of neuronal and non-neuronal cells in lateral habenula in response to threats

Longitudinal assessment of behaviour and neuronal activity in the lateral habenula in a mouse model of depression