lateral habenula

Astroglial modulation of the antidepressant action of deep brain and bright light stimulation

Even if major depression is now the most common of psychiatric disorders, successful antidepressant treatments are still difficult to achieve. Therefore, a better understanding of the mechanisms of action of current antidepressant treatments is needed to ultimately identify new targets and enhance beneficial effects. Given the intimate relationships between astrocytes and neurons at synapses and the ability of astrocytes to "sense" neuronal communication and release gliotransmitters, an attractive hypothesis is emerging stating that the effects of antidepressants on brain function could be, at least in part, modulated by direct influences of astrocytes on neuronal networks. We will present two preclinical studies revealing a permissive role of glia in the antidepressant response: i) Control of the antidepressant-like effects of rat prefrontal cortex Deep Brain Stimulation (DBS) by astroglia, ii) Modulation of antidepressant efficacy of Bright Light Stimulation (BLS) by lateral habenula astroglia. Therefore, it is proposed that an unaltered neuronal-glial system constitutes a major prerequisite to optimize antidepressant efficacy of DBS or BLS. Collectively, these results pave also the way to the development of safer and more effective antidepressant strategies.

Integrating information and reward into subjective value: humans, monkeys, and the lateral habenula

COSYNE 2022

Integrating information and reward into subjective value: humans, monkeys, and the lateral habenula

COSYNE 2022

Acetylcholine and Lateral Habenula partnership in shaping punishment anticipation

Experience-dependent plasticity of burst activity in lateral habenula neurons

Including the lateral habenula in the stress-related functional network

Responses of lateral habenula neurons to an aversive stimulus across alternating brain states of urethane anaesthetised rat

Role of a lateral hypothalamus-lateral habenula pathway in cocaine-induced psychomotor responses

Ventral Pallidum activation differentially modulates the Mediodorsal Thalamus and the Lateral Habenula of rats

Dynamics of neuronal and non-neuronal cells in lateral habenula in response to threats

FENS Forum 2024

Longitudinal assessment of behaviour and neuronal activity in the lateral habenula in a mouse model of depression

FENS Forum 2024

Nigroincertal activation engages lateral habenula and periaqueductal gray

FENS Forum 2024

Plasticity in the lateral habenula after adult-newborn interactions

FENS Forum 2024