TopicNeuroscience

locus coeruleus

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45Total items

40ePosters

5Seminars

Latest

SeminarNeuroscience

Dark Matter in the Locus coeruleus - Neuromelanin in Health and Disease

Matthias Prigge

Leibniz Institute for Neurobiology, University of Magdeburg, Germany

Apr 10, 2025

SeminarNeuroscience

Multimodal investigation of the associations between sleep and Alzheimer's disease neuropathology in healthy individuals

Gilles Vandewalle

University of Liège, Belgium

May 10, 2022

Alterations in sleep are hallmarks of the ageing process and emerges as risk factors for Alzheimer’s disease (AD). While the fine-tuned coalescence of sleep microstructure elements may influence age-related cognitive trajectories, its association with AD-related processes is not fully established. We investigated whether sleep arousals and the coupling of spindles and slow waves, key elements of sleep microstructure, are associated with early amyloid-beta (Aβ) brain burden, hallmark of AD neuropathology, and cognitive change at 2 years in 100 late-midlife healthy individuals. We first found that arousals interrupting sleep continuity were positively linked to Aβ burden, while, by contrast, the more prevalent arousals upholding sleep continuity were associated with lower Aβ burden and better cognition. We further found that young-like co-occurrence of spindles and slow-depolarisation slow waves is associated to lower burden of Aβ over the medial prefrontal cortex and is predictive of memory decline at 2-year follow-up. We provide empirical evidence that arousals are diverse and differently associated with early AD-related neuropathology and cognition. We further show the altered coupling of sleep microstructure elements that are key to its mnesic functions may contribute to poorer brain and cognitive trajectories. The presentation will end with preliminary data show that activity of the locus coeruleus, essential to sleep and showing some of the earliest signs of AD-related pathological processes, is associated with sleep quality. These preliminary findings are the first of a project ailed at link sleep and AD through the locus coeruleus.

SeminarNeuroscience

Neuromodulation of sleep integrity

Luís de Lecea

Stanford University

Apr 12, 2022

The arousal construct underlies a spectrum of behaviors that include sleep, exploration, feeding, sexual activity and adaptive stress. Pathological arousal conditions include stress, anxiety disorders, and addiction. The dynamics between arousal state transitions are modulated by norepinephrine neurons in the locus coeruleus, histaminergic neurons in the hypothalamus, dopaminergic neurons in the mesencephalon and cholinergic neurons in the basal forebrain. The hypocretin/orexin system in the lateral hypothalamus I will also present a new mechanism underlying sleep fragmentation during aging. Hcrt neurons are hyperexcitable in aged mice. We identify a potassium conductance known as the M-current, as a critical player in maintaining excitability of Hcrt neurons. Genetic disruption of KCNQ channels in Hcrt neurons of young animals results in sleep fragmentation. In contrast, treatment of aged animals with a KCNQ channel opener restores sleep/wake architecture. These data point to multiple circuits modulating sleep integrity across lifespan.

SeminarNeuroscienceRecording

NMC4 Short Talk: Two-Photon Imaging of Norepinephrine in the Prefrontal Cortex Shows that Norepinephrine Structures Cell Firing Through Local Release

Samira Glaeser-Khan

Yale University

Dec 2, 2021

Norepinephrine (NE) is a neuromodulator that is released from projections of the locus coeruleus via extra-synaptic vesicle exocytosis. Tonic fluctuations in NE are involved in brain states, such as sleep, arousal, and attention. Previously, NE in the PFC was thought to be a homogenous field created by bulk release, but it remains unknown whether phasic (fast, short-term) fluctuations in NE can produce a spatially heterogeneous field, which could then structure cell firing at a fine spatial scale. To understand how spatiotemporal dynamics of norepinephrine (NE) release in the prefrontal cortex affect neuronal firing, we performed a novel in-vivo two-photon imaging experiment in layer ⅔ of the prefrontal cortex using a green fluorescent NE sensor and a red fluorescent Ca2+ sensor, which allowed us to simultaneously observe fine-scale neuronal and NE dynamics in the form of spatially localized fluorescence time series. Using generalized linear modeling, we found that the local NE field differs from the global NE field in transient periods of decorrelation, which are influenced by proximal NE release events. We used optical flow and pattern analysis to show that release and reuptake events can occur at the same location but at different times, and differential recruitment of release and reuptake sites over time is a potential mechanism for creating a heterogeneous NE field. Our generalized linear models predicting cellular dynamics show that the heterogeneous local NE field, and not the global field, drives cell firing dynamics. These results point to the importance of local, small-scale, phasic NE fluctuations for structuring cell firing. Prior research suggests that these phasic NE fluctuations in the PFC may play a role in attentional shifts, orienting to sensory stimuli in the environment, and in the selective gain of priority representations during stress (Mather, Clewett et al. 2016) (Aston-Jones and Bloom 1981).

SeminarNeuroscienceRecording

Context-Dependent Relationships between Locus Coeruleus Firing Patterns and Coordinated Neural Activity in the Anterior Cingulate Cortex

Siddhartha Joshi

Baylor College of Medicine

Oct 8, 2021

Ascending neuromodulatory projections from the locus coeruleus (LC) affect cortical neural networks via the release of norepinephrine (NE). However, the exact nature of these neuromodulatory effects on neural activity patterns in vivo is not well understood. Here we show that in awake monkeys, LC activation is associated with changes in coordinated activity patterns in the anterior cingulate cortex (ACC). These relationships, which are largely independent of changes in firing rates of individual ACC neurons, depend on the type of LC activation: ACC pairwise correlations tend to be reduced when tonic (baseline) LC activity increases but are enhanced when external events drive phasic LC responses. Both relationships covary with pupil changes that reflect LC activation and arousal. These results suggest that modulations of information processing that reflect changes in coordinated activity patterns in cortical networks can result partly from ongoing, context-dependent, arousal-related changes in activation of the LC-NE system.

locus coeruleus

Latest

Dark Matter in the Locus coeruleus - Neuromelanin in Health and Disease

Multimodal investigation of the associations between sleep and Alzheimer's disease neuropathology in healthy individuals

Neuromodulation of sleep integrity

NMC4 Short Talk: Two-Photon Imaging of Norepinephrine in the Prefrontal Cortex Shows that Norepinephrine Structures Cell Firing Through Local Release

Context-Dependent Relationships between Locus Coeruleus Firing Patterns and Coordinated Neural Activity in the Anterior Cingulate Cortex

CHRONIC TWO-PHOTON CALCIUM IMAGING OF ASTROCYTES, PYRAMIDAL CELLS AND INTERNEURONS DURING NATURAL AROUSAL AND OPTOGENETIC STIMULATION OF LOCUS COERULEUS

REDUCED NORADRENERGIC EXCITABILITY IN THE LOCUS COERULEUS COMPROMISES NOCICEPTIVE INHIBITION IN A DIABETIC MOUSE MODEL

LOCUS COERULEUS SIGNALS SIGNED VISUOMOTOR PREDICTION ERRORS THAT DEPEND ON TASK CONTEXT

EARLY Α-SYNUCLEIN PATHOLOGY IN THE LOCUS COERULEUS DISRUPTS NORADRENERGIC CIRCUITS AND HIPPOCAMPAL FUNCTION IN A PRODROMAL PARKINSON’S DISEASE MODEL

RECONSTRUCTION OF AXONAL COLLATERALS FROM SPARSE LOCUS COERULEUS NORADRENERGIC (LC-NA) NEURONS REVEALS THEIR MODULAR AXON PROJECTIONS

ASTROCYTES REGULATE PHASIC ACTIVATION OF LOCUS COERULEUS NOREPINEPHRINE NEURONS VIA NMDA RECEPTOR-DEPENDENT PLASTICITY

ROLE OF THE LOCUS COERULEUS NORADRENERGIC SYSTEM IN SUSCEPTIBILITY AND RESILIENCE FOLLOWING EARLY LIFE STRESS IN MALE AND FEMALE MICE

TOPOGRAPHY OF GALANIN AND NEUROPEPTIDE-Y LOCUS COERULEUS NEURONS AND THEIR HIPPOCAMPAL OUTPUTS

A CONSERVED LOCUS COERULEUS FMRI SIGNATURE OF BRAIN-STATE TRANSITIONS ACROSS SLEEP, ANESTHESIA, AND WAKEFULNESS

EXPLORING SUBTHALAMIC INFLUENCE ON LOCUS COERULEUS NORADRENERGIC NEURONS

Β₂-ADRENOCEPTOR AGONIST FORMOTEROL ATTENUATES DEFICITS IN DELAYED NON-MATCH TO POSITION TASK FOLLOWING SYSTEMIC LPS CHALLENGE AND BILATERAL LPS DELIVERY INTO THE LOCUS COERULEUS IN RATS

ELECTROPHYSIOLOGICAL CHARACTERIZATION OF THE LOCUS COERULEUS NETWORK IN A RODENT MODEL OF PRODROMAL PARKINSON’S DISEASE

TRANSCRANIAL ULTRASONIC STIMULATION TARGETED TO THE LOCUS COERULEUS INDUCES PARAMETER-DEPENDENT CHANGES IN HIPPOCAMPAL NORADRENALINE LEVELS

TRACKING THE EARLY DEVELOPMENT AND FUNCTIONAL DIVERSITY OF THE ZEBRAFISH LOCUS COERULEUS AND NORADRENERGIC SYSTEM

ASTROCYTE–NORADRENERGIC INTERACTIONS IN THE LOCUS COERULEUS SHOW SEX-SPECIFIC CHANGES IN EARLY ALZHEIMER’S DISEASE

ELEVATED LOCUS COERULEUS OUTPUT DURING UNEXPECTED EVENTS IN A MOUSE MODEL OF FRAGILE X SYNDROME

CHEMOGENETIC STIMULATION OF THE LOCUS COERULEUS INCREASES RESILIENCE TO PATHOLOGY IN A TRANSGENIC RAT MODEL OF ALZHEIMER'S DISEASE

BRAINSTEM ASTROCYTIC METABOLIC ALTERATIONS UNDERLYING SEX-SPECIFIC LOCUS COERULEUS VULNERABILITY IN ALZHEIMER’S DISEASE

DYRK1A OVEREXPRESSION INCREASES NORADRENERGIC TONE AND IMPAIRS CONTEXTUAL MEMORY THROUGH LOCUS COERULEUS DYSREGULATION IN BAC-DYRK1A MICE

CROSSTALK BETWEEN METABOTROPIC GLUTAMATE, OPIOID, AND ALPHA-2 ADRENORECEPTORS IN LOCUS COERULEUS NEURONS

LOCUS COERULEUS DYSFUNCTION LEADS TO HIGHER REM PRESSURE IN AGING

<FONT DIR="AUTO" STYLE="VERTICAL-ALIGN: INHERIT;"><FONT DIR="AUTO" STYLE="VERTICAL-ALIGN: INHERIT;">PAPEL DE LAS NEURONAS NORADRENÉRGICAS DEL LOCUS COERULEUS EN LA ANSIEDAD Y DEPRESIÓN COMÓRBIDAS EN UN MODELO DE RATONES CON ENFERMEDAD DE PARKINSON</FONT></FONT>

DIVERGENT ROLES OF LOCUS COERULEUS IN PAIN MODULATION AND PUPILLARY DYNAMICS

PROSTAGLANDIN EP3 RECEPTOR SIGNALLING AS A CONTRIBUTOR TO SEX DIFFERENCES IN STRESS-RELATED DISORDERS MEDIATED BY THE LOCUS COERULEUS

Activity-dependent beta-adrenergic modulation by the locus coeruleus of recent and remote spatial memory

Characterization of astroglia-noradrenergic neuron communication in the locus coeruleus

Chemogenetic activation of the locus coeruleus increases hippocampal noradrenaline levels leading to modulation of hippocampal excitability

Deciphering the role of locus coeruleus for hippocampus-dependent learning and its impairment in a mouse model of Alzheimer’s disease

Deciphering the role of locus coeruleus through salient stimulus detection using functional MRI

The effects of CRF agonists and antagonists on the noradrenaline released from the locus coeruleus and the serotonin released from the raphe nuclei

Functional, behavioural and molecular characterization of a presymptomatic model of Parkinson disease expressing α-synuclein in the locus coeruleus

Identification of excitatory presynaptic neurons participating in regulation of noradrenergic neurons in the locus coeruleus

Impaired modulation of trigeminal caudal nucleus somatosensory responses by the locus coeruleus in a mouse model of diabetes: Participation of GABAergic and glycinergic neurons

The locus coeruleus noradrenergic network in prodromal phases of Parkinson’s disease

Noradrenergic locus coeruleus activity functionally partitions NREM sleep to gatekeep the NREM-REM sleep cycle

Properties of the synaptic transmission from medial prefrontal cortex to locus coeruleus

Rate of neuromelanin accumulation in the locus coeruleus is a critical factor for neurodegeneration

Targeting norepinephrine neurons of the locus coeruleus: A comparison of model systems and strategies

Defining the role of a locus coeruleus-orbitofrontal cortex circuit in behavioral flexibility

Transcutaneous vagus nerve stimulation (tVNS) as a therapeutic approach towards the functional deterioration of the locus coeruleus–noradrenergic system