LSD

Psychedelics and the Pharmacology of Consciousness

The study of altered states of consciousness has long had the potential to provide important insight into the nature of consciousness. In recent years there has been a resurgence of research and public interest in atypical or altered states of consciousness. These have focused both on conditions in which consciousness is considered to be impaired due to brain trauma or enhanced in some way through mediation practices or ingestion of psychedelics. The talk will begin with a brief overview of recent scientific approaches to understanding these different types of altered consciousness. The remainder of the talk will focus on lab-based experiments conducted by myself and others looking at the effects of serotoninergic hallucinogens (i.e. psilocybin and LSD) on perceptual and cognitive function. Together this body of research provides important new insights for the scientific study of consciousness and an initial understanding of the neuropharmacological mechanisms underlying conscious experience.

TARGETING LSD1 PROMOTES NEUROPROTECTION AND FUNCTIONAL RECOVERY AFTER ISCHEMIC STROKE

FENS Forum 2026

POTENTIATING LSD1 AS AN EMERGING THERAPEUTIC APPROACH TO PRESERVE ADAPTIVE FEAR MEMORY UPDATING

FENS Forum 2026

TARGETING LSD1 TO REDUCE NEUROINFLAMMATION AND PROMOTE FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY

FENS Forum 2026

IN VITRO ASSESSMENT OF D2 DOPAMINE RECEPTOR-INDUCED MICROEXON 8A INCLUSION IN LSD1: AN EPIGENETIC FATE UNDER DOPAMINE CONTROL

FENS Forum 2026

MALAT1–NSR100–LSD1: A CONSERVED REGULATORY AXIS CONTROLLING STRESS ADAPTATION

FENS Forum 2026

EFFECTS OF NOVEL LSD DERIVATIVES ON ALCOHOL CONSUMPTION AND MOTIVATIONAL REWARD IN MALE AND FEMALE RATS

FENS Forum 2026

A novel role for LSD1 splicing modulation in homeostatic adaptation to chronic stress

FENS Forum 2024

Whole-brain mapping and behavioural assessments of the effect of different doses of LSD in mice

FENS Forum 2024

2-Bromo-LSD: A non-hallucinogenic LSD analogue with therapeutic potential for Major Depressive Disorder

Evolution increases stress-response complexity in higher primates extending RbFOX1 splicing activity to LSD1 modulation

LSD1 inhibition improves functional outcome after spinal cord injury

Cortical transcriptomic effects of the non-hallucinogenic 2-bromo LSD

FENS Forum 2024

Extending MALAT1 activity to the modulation of LSD1 alternative splicing: A novel cell-autonomous mechanism devoted to neuronal homeostasis

FENS Forum 2024