MCT

Evolution of convulsive therapy from electroconvulsive therapy to Magnetic Seizure Therapy; Interventional Neuropsychiatry

In April, we will host Nolan Williams and Mustafa Husain. Be prepared to embark on a journey from early brain stimulation with ECT to state-of-the art TMS protocols and magnetic seizure therapy! The talks will be held on Thursday, April 25th at noon ET / 6PM CET. Nolan Williams, MD, is an associate professor of Psychiatry and Behavioral Science at Stanford University. He developed the SAINT protocol, which is the first FDA-cleared non-invasive, rapid-acting neuromodulation treatment for treatment-resistant depression. Mustafa Husain, MD, is an adjunct professor of Psychiatry and Behavioral Sciences at Duke University and a professor of Psychiatry and Neurology at UT Southwestern Medical Center, Dallas. He will tell us about “Evolution of convulsive therapy from electroconvulsive therapy to Magnetic Seizure Therapy”. As always, we will also get a glimpse at the “Person behind the science”. Please register va talks.stimulatingbrains.org to receive the (free) Zoom link, subscribe to our newsletter, or follow us on Twitter/X for further updates!

Deep learning for model-based RL

Model-based approaches to control and decision making have long held the promise of being more powerful and data efficient than model-free counterparts. However, success with model-based methods has been limited to those cases where a perfect model can be queried. The game of Go was mastered by AlphaGo using a combination of neural networks and the MCTS planning algorithm. But planning required a perfect representation of the game rules. I will describe new algorithms that instead leverage deep neural networks to learn models of the environment which are then used to plan, and update policy and value functions. These new algorithms offer hints about how brains might approach planning and acting in complex environments.

Cortical pyramidal cells express thyroid hormone transporters MCT8 and OATP1C1 in human and monkey brain

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

Loss of MCT4 in microglia results in altered brain development and anxiety-like behavior

Thyroid hormone transporters MCT8 and OATP1C1 are expressed in neurons in the human and monkey basal ganglia and motor thalamus

Allan-Herndon-Dudley syndrome – Uncovering disease mechanisms of MCT8-deficiency in the hypothyroid developing brain using snRNAseq

FENS Forum 2024

Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice

FENS Forum 2024

Unravelling the role of microglial MCT4 in ischemic stroke

FENS Forum 2024