metabolomic profiling
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Metabolic Remodelling in the Developing Forebrain in Health and Disease
Little is known about the critical metabolic changes that neural cells have to undergo during development and how temporary shifts in this program can influence brain circuitries and behavior. Motivated by the identification of autism-associated mutations in SLC7A5, a transporter for metabolically essential large neutral amino acids (LNAAs), we utilized metabolomic profiling to investigate the metabolic states of the cerebral cortex across various developmental stages. Our findings reveal significant metabolic restructuring occurring in the forebrain throughout development, with specific groups of metabolites exhibiting stage-specific changes. Through the manipulation of Slc7a5 expression in neural cells, we discovered an interconnected relationship between the metabolism of LNAAs and lipids within the cortex. Neuronal deletion of Slc7a5 influences the postnatal metabolic state, resulting in a shift in lipid metabolism and a cell-type-specific modification in neuronal activity patterns. This ultimately gives rise to enduring circuit dysfunction.
SERUM <SUP>1</SUP>H-NMR METABOLOMIC PROFILING DISTINGUISHES OCB TYPE 1 AND TYPE 2 PATTERNS IN EARLY POSSIBLE MULTIPLE SCLEROSIS
FENS Forum 2026
TARGETED METABOLOMIC PROFILING OF ASTROCYTE LYSATES, CONDITIONED MEDIA AND EXTRACELLULAR VESICLES
FENS Forum 2026
Metabolomic profiling unveils novel insights into multiple sclerosis pathogenesis
FENS Forum 2024
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