TopicNeuroscience

methamphetamine

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13Total items

11ePosters

1Grant

1Seminar

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GrantNeuroscience

TACTIC: Tuberculosis Active Case Tracking via Interpersonal Connections

National Institute of Allergy and Infectious Diseases

May 31, 2031

PROJECT SUMMARY/ABSTRACT Tuberculosis (TB) remains the leading infectious cause of death worldwide. Interruption of transmission is the most effective strategy to reduce incident infections, yet current approaches often fail to reach individuals for timely testing and treatment. This study addresses that gap by leveraging social networks to identify individuals at highest risk of transmitting TB, specifically, people who use drugs (PWUD). We will evaluate respondent-driven sampling (RDS), a peer7 based community recruitment strategy, to identify TB cases among PWUD and the household contacts (HHCs) of those with TB disease (RDS-TB) in Kampala, Uganda. Conducting this work in a high-prevalence setting such as Kampala where our team has established expertise allows us to overcome recruitment challenges common in settings in the United States while generating findings that are directly translatable. This is particularly relevant given that higher TB prevalence and larger outbreaks in the United States have been associated with the use of methamphetamine, heroin, and crack/cocaine, drugs that we will study. In Aim 1, we will compare the effectiveness and reach of RDS-TB with a traditional clinic-based index case HHC approach for TB case finding. We will screen 2,000 PWUD and their HHCs, estimate the number needed to screen to identify one case of TB disease, and compare the demographic and network characteristics of RDS-TB recruits with clinic-based HHCs. Whole genome sequencing will be used to characterize transmission dynamics. In Aim 2, we will compare the yield of individual and combined TB diagnostic strategies for community-based active case finding. Participants will undergo chest radiography with computer-aided detection, tongue swab testing for TB nucleic acid amplification tests (NAAT), and sputum testing for NAAT and mycobacterial culture. We will identify the minimal combination of tests needed to meet World Health Organization target product profile thresholds for screening. In Aim 3, we will define the conditions under which RDS-based screening can effectively interrupt TB transmission. We will develop an agent-based model informed by social network data from individuals with and without TB, incorporating drug use patterns and demographic characteristics. This project will generate a practical, scalable roadmap for social network–based TB active case finding in high28 risk communities. The approach will be readily adaptable to settings in the United States and will inform strategies to interrupt transmission and advance progress toward TB elimination, in alignment with the NIH Strategic Plan for TB Research.

SeminarNeuroscience

Choice between methamphetamine and food is modulated by reinforcement interval and central drug metabolism

Acupuncture decreases brain temperature induced by methamphetamine via RMTg

Namjun Kim, Bong Hyo Lee

ePosterNeuroscience

Does early postnatal methamphetamine administration along with altered environment affect neurotransmitter and oxidative stress levels in adolescence of laboratory rat?

Barbora Cechova, Jana Jurcovicova, Simon Vaculin, Stepan Sandera, Romana Slamberova

ePosterNeuroscience

Does paternal methamphetamine exposure cause such a serious impact to rat offspring during development and in adulthood as maternal drug exposure?

Lydia Mihalcikova, Anna Bednarikova, Romana Slamberova

ePosterNeuroscience

HIV-1 Tat protein exacerbates methamphetamine-dysregulated dopamine uptake into vesicular monoamine transporter-2 and potentiates methamphetamine conditioned place preference in HIV-1 Tat transgenic mice

Jun Zhu, Matthew J. Strauss1, Sarah E. Davis1, Jay P. Mclaughlin

ePosterNeuroscience