In the fourth of this year’s Brain Prize webinars, Mike Fainzilber (Weizmann Institute of Science, Israel), Yingxi Lin (UT Southwestern, USA), and Richard Tsien (New York University, USA) will present their work on synapse to nucleus signalling. Each speaker will present for 25 minutes, and the webinar will conclude with an open discussion. The webinar will be moderated by two of the winners of the 2023 Brain Prize, Michael Greenberg and Erin Schuman.