TopicNeuro
motor neuron degeneration
1 Seminar1 ePoster
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SeminarNeuroscience
Zebrafish models help untangle genetic interactions in motor neuron degeneration
Sorana Ciura
Imagine Institute, Université de Paris
May 31, 2022
Due to high homology to the human genome and rapid development, zebrafish have been successfully used to model diseases of the neuromuscular system. In this seminar, I will present current advances in modeling genetic causes of Amyotrophic Lateral Sclerosis (ALS), the most common motor neuron degeneration and show how epistatic interaction studies in zebrafish have helped elucidate synergistic effects of major ALS genes and their cellular targets.
ePosterNeuroscience
The knocking-down of the restrictive element 1-silencing transcription factor (REST) improves symptoms and limits motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis
Natascia Guida, Valeria Valsecchi, Serenella Anzilotti, Ornella Cuomo, Luca Sanguigno, Pignataro Giuseppe, Lucio Annunziato, Luigi Formisano
FENS Forum 2024
motor neuron degeneration coverage
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