neuronal damage

Roles of microglia in the pathogenesis of neurodegeneration

Microglia are implicated in a variety of functions in the central nervous system, ranging from shaping neural circuits during early brain development, to surveying the brain parenchyma, and providing trophic support to neurons across the entire lifespan. In neurodegeneration, microglia have been considered for long time mere bystanders, accompanying and worsening neuronal damage. However, recent evidence indicates that microglia can causally contribute to neurodegenerative diseases, and that their dysfunction can even be at the origin of the pathology. In fact, the broad range of physiological roles microglia play in the healthy brain suggest that faulty microglia can initiate neurodegeneration through several possible mechanisms. In particular, in this seminar, we will discuss how dysfunctional microglia can affect synaptic function leading to pathological synapse loss, thus putting microglia center stage in the pathogenesis of brain disorders.

Insulin-like growth factor II neuroprotective effects against mitochondrial-oxidative and neuronal damage induced by CORT and MPP+ in dopaminergic neurons

Novel mechanism of hypoxic neuronal damage mediated by non-excitatory amino acids and astroglial swelling

Serum myeloperoxidase, but not the cerebrospinal-fluid enzyme, is closely linked to clinical features and neuronal damage in idiopathic Parkinson´s disease

The effect of TRPM2 inhibition on 4-AP-induced seizure in mouse brain slice and 4-AP-induced neuronal damage in HT-22 mouse hippocampal neuronal cell line

FENS Forum 2024

Exploring the neuroprotective effects of nicotine against MPTP-induced neuronal damage in mice: Insights into antioxidant system

FENS Forum 2024